Title OSOBITOSTI UPALNIH BOLESTI CRIJEVA U ZADARSKOJ ŽUPANIJI Title (english) Specific features of inflammatory bowel disease iu Zadar County Author Ivo Klarin Mentor Aleksandar Včev (mentor)Committee member Dinko Puntarić (predsjednik povjerenstva)Granter Josip Juraj Strossmayer University of Osijek Defense date and country 2014-10-29, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Universal decimal classificationUDC ) 61 - Medical sciences Abstract Cilj istraživanja: utvrditi incidenciju i prevalenciju upalnih bolesti crijeva (Crohnova bolest i ulcerozni kolitis) u pučanstvu Zadarske županije u razdoblju od 2000 - 2010 godine, analizirati fenotipove obje bolesti, ustanoviti učestalost komlikacija, te istražiti utjecaj potencijalnih čimbenika rizika okoliša. Nacrt studije: retrospektivno – prospektivna epidemiološka studija Ispitanici i metode: u studiju je uključeno 397 pacijenata s upalnim bolestima crijeva, 243 muškarca i 154 žene, koji svi žive na području Zadarske županije. Za procjenu čimbenika rizika je formirana kontrolna skupina od 1000 zdravih dobrovoljaca koji također žive na području Zadarske županije. Za svakog oboljelog ispunjena su dva protokola, za incidenciju i prevalenciju upalnih bolesti crijeva. Fenotip Crohnove bolesti i ulceroznog kolitisa određen je prema Montrealskoj klasifikaciji upalnih bolesti crijeva. Rezultati: Pokazana je blaga predominacija ulceroznog kolitisa nad Crohnovom bolesti, te veći broj oboljelih muškaraca kod obje bolesti. Godišnja stopa incidencije za razdoblje 2000-2010 za ulcerozni kolitis iznosi 8,1/100.000 stanovnika, a za Crohnovu bolest 8,3/100.000. Prevalencija na kraju 2010 godine za ulcerozni kolitis iznosi 128,39/100.000 stanovnika, a za Crohnovu bolest 106,5/100.000 stanovnika. Bolesnici s Crohnovom bolesti su mlađi (31,9 godina) od bolesnika s ulceroznim kolitisom (42,4 godine) u trenutku postavljanja dijagnoze. Kod bolesnika s ulceroznim kolitisom najčešće je zahvaćeno cijelo debelo crijevo (fenotip E3). Bolesnici s Crohnovom bolesti su najčešće stari između 17 i 40 godina (fenotip A2), najčešće je zahvaćen terminalni ileum (L1), te imaju nekomplicirani tijek bolesti (B1). Komplikacije bolesti su češće kod Crohnove bolesti. Nađena je statistički značajna povezanost upalnih bolesti crijeva i pušenja, apendektomije i cijepljenja protiv ospica, dok te povezanosti ne postoji s tonzilektomijom, uzimanjem oralnih kontraceptiva i preboljelim ospicama. Pušenje utječe na učestalost komplikacija kod bolesnika s Crohnovom bolesti. Statistički je značajna obiteljska agregacija upalnih bolesti crijeva. Zaključak: epidemiologija upalnih bolesti crijeva se najbolje uklapa u europski „model zapad-istok“. Dobiveni su točni brojčani podatci za jednu dalmatinsku županiju, koji mogu temelj za daljnja istraživanja.
Abstract (english) Aim of study: To determine the incidence and prevalence of inflammatory bowel disease (Crohn's disease and ulcerative colitis ) in the population of Zadar County in the period 2000-2010 , to analyse phenotypes of both diseases, to determine the frequency of complication, and explore the impact of potential enviromental risk factors. Study design : retrospective – prospective epidemiological study Patients and Methods : The study included 397 patients with inflammatory bowel disease , 243 men and 154 women , who all live in Zadar County . To assess risk factors formed a control group of 1,000 healthy volunteers who also live in Zadar County. For each patient met the two protocols , the incidence and prevalence of inflammatory bowel disease. Phenotype of Crohn`s disease and ulcerative colitis is determined by the Montreal classification of inflamatory bowel disease. Results : The higher the incidence of ulcerative colitis compared to Crohn's disease. In both diseases is increasing the number of male patients.. The annual incidence rate for the period 2000-2010 for ulcerative colitis is 8.1 / 100,000 inhabitans , while Crohn's disease is 8.3 / 100,000 . Prevalence at the end of 2010 for ulcerative colitis is 128,39 / 100,000 inhabitans , while Crohn's disease is 106,5/100.000 inhabitants. Patients with Crohn's disease were younger (31.9 years) than patients with ulcerative colitis (42.4 years) at the time of diagnosis. Patients with ulcerative colitis usually affected the entire colon (phenotype E3) . Patients with Crohn's disease are usually aged between 17 and 40 (phenotype A2) , the most affected is terminal ileum (L1), and have uncomplicated disease course (B1) . Complications of the disease are more common in Crohn's disease. Discovered connection between inflammatory bowel disease and smoking, appendectomy, and vaccination against measles, while not a proven link with tonsillectomy, oral contraceptives an measles in history . Smoking affects the incidence of complications in patients with Crohn's disease. There is a statistically significant family agggregation of inflamatory bowel disease. Conclusion: The epidemiology of inflammatory bowel disease can best fit into the European " model west-east ." Obtained are accurate numerical data for one Dalmatia County, which can be the basis for further research.
Keywords
Crohnova bolest
Ulcerozni kolitis
Zadarska županija
Keywords (english)
Crhon's disease
colitic
ulcerative
Zadar County
Language croatian URN:NBN urn:nbn:hr:152:155240 Study programme Title: University Postgraduate Study Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2017-06-02 09:53:32
