Objectives: The aim of the study was to recognize phenothype features of primary and recurrent transitional cell urinary bladder carcinoma associated with an increased risk of early or late disease reccurence. Immunohistochemical markers EGFR, HER2, HER3, MLH1, MSH2, MSH6, PMS2 and E-cadherin were compared with the surrogate marker Ki-67 in the primary and recurrence carcinoma. The aim of the study was to identify differences in the immunohistochemical carcinoma phenotype in subgroups that would indicate differences in their biology, and to determine whether carcinoma relapsing originates from the primary carcinoma or a new formation of similar but different carcinomic phenotype. Study design: Immunohistochemical predictors of cancer recurrence were analysed in all subgroups of patients and their effects on recurrence rate, recurrence sequence, time between occurrence of subsequent recurrences were determined as well as the age of the patient at the time of first carcinoma appearance. Patients and methods: The study included archic tissue samples of 33 patients with recurrent transitional cell urinary bladder carcinoma and processing on Deparment of Pathology, University Hospital Osijek. All tumors were analyzed immunohistochemically on six characteristics, the results of immunohistochemical staining were expressed by semiquantitative method ranging from ( - ) to (+ + +). A positive reaction was taken to range between moderately positive (+ +) and a very positive response (+ + +) and negative reaction between negative (-) and poorly positive reaction (+). The MARS method was used to evaluate the predictive value of the indicators. Results: Of all the tested indicators, it was conclusively found that the markers from the HER and Lynch family were of great importance for certain subgroups of these cancers, while E-cadherin did not have an essential role in the cancer recidivation process. The number of recurrences depended on the age of the patient at the time of the onset of first cancer. In the initial carcinoma, the main predictors were HER2 and MSH2, in the early recurrence EGFR and HER3, and in late recurrences EGFR. In the prediction of Ki-67 values, the predictor of early recurrence was MSH2 and MSH6, and for the first relapse MSH6. Conclusion: Urinary bladder transitional cell carcinoma is a unique clinical entity for its recurrence availability. Immunohistochemical profiling of markers for Lynch and HER family showed complex differences between early and late recurrent carcinoma.