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master's thesis
Genetički uzroci neplodnosti u istočnoj Slavoniji
2016. urn:nbn:hr:152:526714
Ivanković, Tea
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Ivanković, T. (2016). Genetički uzroci neplodnosti u istočnoj Slavoniji (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:526714

Ivanković, Tea. "Genetički uzroci neplodnosti u istočnoj Slavoniji." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2016. https://urn.nsk.hr/urn:nbn:hr:152:526714

Ivanković, Tea. "Genetički uzroci neplodnosti u istočnoj Slavoniji." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2016. https://urn.nsk.hr/urn:nbn:hr:152:526714

Ivanković, T. (2016). 'Genetički uzroci neplodnosti u istočnoj Slavoniji', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 03 April 2025, https://urn.nsk.hr/urn:nbn:hr:152:526714

Ivanković T. Genetički uzroci neplodnosti u istočnoj Slavoniji [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2016 [cited 2025 April 03] Available at: https://urn.nsk.hr/urn:nbn:hr:152:526714

T. Ivanković, "Genetički uzroci neplodnosti u istočnoj Slavoniji", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:152:526714

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Metadata
TitleGenetički uzroci neplodnosti u istočnoj Slavoniji
Title (english)Genetic causes of infertility in eastern Slavonia region
AuthorTea Ivanković
MentorJasenka Wagner (mentor)
Committee memberMarija Heffer (predsjednik povjerenstva)
Committee memberSiniša Šijanović (član povjerenstva)
Committee memberJasenka Wagner (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2016-07-20, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract
Ciljevi istraživanja: Utvrditi broj neplodnih parova koji su se javili u Genetičko savjetovalište KBC-a Osijek, odrediti omjer pacijenata registriranih u savjetovalištu i onih poslanih na kariotipizaciju, odrediti postotak parova s dokazanim genetičkim uzrokom infertiliteta, odrediti pojavnost genetičkih entiteta, usporediti dobivene rezultate s drugim nacionalnim istraživanjima ili zemljama iz okruženja. Ustroj studije: Istraživanje je retrospektivno. Ispitanici i metode: Pregled medicinske... More dokumentacije infertilnih parova obrađenih u KBC-u Osijek i Laboratoriju za medicinsku genetiku Medicinskog fakulteta Osijek 2006. - 2016. godine. Rezultati: U KBC-u Osijek ukupno je obrađeno 982 para 2006. – 2016. godine. Iz Ambulante za humanu reprodukciju obrađeno je 857 parova, od kojih je 21 par (2,3 %) imao nalaz kariograma. Broj parova registriranih u Genetičkom savjetovalištu bio je 135. Od toga je 126 parova i 1 muškarac (93,7 %) poslano na kariotipizaciju. Za 275 osoba napravljen je barem jedan genetički test, uključujući kariogram. Genetički uzrok infertiliteta nađen je kod 16 parova: 13 žena i 3 muškarca. Zaključak: U desetogodišnjem razdoblju u Genetičko savjetovalište KBC-a Osijek javilo se 135 neplodnih parova, 93,7 % poslano je na kariotipizaciju. Sveukupno je nalaz kariograma imalo 275 osoba. Genetički uzrok infertiliteta dokazan je kod 5,81 % pacijenata obrađenih genetičkim testovima, i kod 11,85 % parova iz Genetičkog savjetovališta. Utvrđeni genetički uzroci infertiliteta: Turnerov sindrom, Klinefelterov sindrom, delecija Y kromosoma, nositelji kromosomske translokacije, MTHFR homozigoti, PAI-1 polimorfizmi. Pojavnost mikrodelecije Y kromosoma, MTHFR i PAI-1 mutacija bila je slična pojavnosti u drugim studijama. Pojavnost ostalih entiteta bila je niža nego u drugim studijama. Less
Abstract (english)
Objectives: The aim of this study was to determine the number of infertile couples registered at Clinical Hospital Center Osijek, to determine the ratio of patients registered and those with karyotype test result, to determine the percentage of couples with identified genetic cause of infertility, to determine the prevalence of genetic entities and to compare these results to other national research results or research results from other countries in the region. Study design: The research... More was retrospective. Material and methods: Analysis of medical documentation of infertile couples registered at Clinical Hospital Center Osijek and Medical faculty Osijek from 2006 to 2016. Results: There were 982 couples treated at Clinical Hospital Center Osijek. Out of 857 couples at the Clinic for Gynecology and Obstetrics, 21 couples were subjected to karyotyping test analysis. The number of couples registered at Clinic for Genetic Counseling was 135 and 126 couples and 1 man (93.2 %) had a karyotype test result. 275 patients were subjected to at least one genetic test. Genetic cause of infertility was found in 16 patient, or 16 couples: in 13 women and 3 men. Conclusion: In a ten-year period there were 135 couples registered at Clinic for Genetic Counseling at Clinical Hospital Center Osijek, 93.2 % were subjected to karyotypes test. 275 people had a karyotyping test analysis. Genetic cause of infertility was determined in 5.81 % patients, of those who underwent at least one genetic test and in 11.85 % of couples at Clinic for Genetic Counseling. The following genetic causes contributing to infertility were identified: Turner´s syndrome, Klinefelter´s syndrome, terminal deletion of the Y chromosome, carriers of chromosomal translocation, MTHFR homozygous gene mutations, PAI-1 polymorphisms. Prevalence of Y chromosome deletions, MTHFR and PAI-1 mutations was similar to prevalence obtained in other studies. Prevalence of remaining genetic entities was found lower in comparison to those in other studies. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:526714
Study programmeTitle: University Graduate Studies
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2016-10-10 11:37:57
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