Background: Systemic sclerosis is a chronic autoimmune systemic disease of the connective tissue with unknown etiology characterized by inflammatory, vascular and fibrous skin and internal organs’ anomalies. It is most frequently found in women. Therapy is still limited and organ-specific. This study aims to determine the connection between the serological profile of the autoimmune antibodies, the clinical manifestations and the disease outcomes. Patients and methods: The study encompasses all the patients from the Department of Rheumatology, Clinical Immunology and Allergology, University Hospital Centre Osijek with the predetermined diagnosis of systemic sclerosis in the period between 31.12.2009 - 31.12.2019. Results: Results confirm the well-known ratio of morbidity between man and female population and point to an increased prevalence of lcSSc within the analyzed population. The connection between the presence of the anti-SCL 70 antibodies, the diffuse form of the disease and the diffuse colour pattern of the immunofluorescence test with the appearance of pulmonary symptoms has been confirmed. Conclusion: In our research, we demonstrated that the appearance of the anti-SCL 70 antibodies is a highly specific marker in the pulmonary involvement in systemic sclerosis. The diffuse form of systemic sclerosis has shown a great affinity to the pulmonary symptoms development of systemic sclerosis. The diffuse staining pattern of the immunofluorescence test has shown a correlation to the presence of pulmonary symptoms specific to systemic sclerosis.