Aims of the study. To determine how acetylsalicylic acid affects platelet aggregation and outcome of the vascular surgery. Material and methods: In the retrospective study 114 medical records and anesthesia charts of patients undergoing vascular surgery in the period from 2009 to 2016 year were analyzed. A total of 72 patients were treated with acetylsalicylic acid and 42 patients did not have data about taking it. Demographic data, operative parameters, frequency of complications such as acute myocardial infarction and mortality were compared with the outcome of vascular surgeries for patients who do not take acetylsalicylic acid. All data were entered and analyzed using t-test and χ2 or Fisher exact test. Results: Demographic data were not different between groups. There were 54 male and 18 female patients in group taking acetylsalicylic acid and 28 male and 14 female patients in group without anti-aggregation therapy. The age of the patients ranged from 37 to 80 years in the first group. In the second group, age range was from 51 to 79 years. The average value of platelet aggregation in the first group was 53.5. The average value in the second group was 66.4. The research confirmed the assumption that the value of platelet aggregation of patients taking aspirin will be within the normal range. One death occurred in both groups and six postoperative hematomas were registered only in the acetylsalicylic acid group. Due to the small number of the patients, differences were not statistically significant. Conclusion: Platelet aggregation was within reference values in this study group. In line with current recommendations, acetylsalicylic acid must not be abolished prior to the surgery. Its’ use however, demands adequate hemostasis and careful postoperative monitoring of patients.