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master's thesis
Razlika u težini motoričkih i nemotoričkih simptoma između bolesnika s Parkinsonovom bolesti ranog i kasnog početka
2022. urn:nbn:hr:152:367533
Horvat, Lovro
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Horvat, L. (2022). Razlika u težini motoričkih i nemotoričkih simptoma između bolesnika s Parkinsonovom bolesti ranog i kasnog početka (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:367533

Horvat, Lovro. "Razlika u težini motoričkih i nemotoričkih simptoma između bolesnika s Parkinsonovom bolesti ranog i kasnog početka." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2022. https://urn.nsk.hr/urn:nbn:hr:152:367533

Horvat, Lovro. "Razlika u težini motoričkih i nemotoričkih simptoma između bolesnika s Parkinsonovom bolesti ranog i kasnog početka." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2022. https://urn.nsk.hr/urn:nbn:hr:152:367533

Horvat, L. (2022). 'Razlika u težini motoričkih i nemotoričkih simptoma između bolesnika s Parkinsonovom bolesti ranog i kasnog početka', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 19 November 2024, https://urn.nsk.hr/urn:nbn:hr:152:367533

Horvat L. Razlika u težini motoričkih i nemotoričkih simptoma između bolesnika s Parkinsonovom bolesti ranog i kasnog početka [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2022 [cited 2024 November 19] Available at: https://urn.nsk.hr/urn:nbn:hr:152:367533

L. Horvat, "Razlika u težini motoričkih i nemotoričkih simptoma između bolesnika s Parkinsonovom bolesti ranog i kasnog početka", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:152:367533

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Metadata
TitleRazlika u težini motoričkih i nemotoričkih simptoma između bolesnika s Parkinsonovom bolesti ranog i kasnog početka
Title (english)Difference in severity of motor and nonmotor symptoms between young onset and old onset Parkinson`s disease patients
AuthorLovro Horvat
MentorSvetlana Tomić (mentor)
Committee memberDunja Degmečić (predsjednik povjerenstva)
Committee memberStjepan Jurić (član povjerenstva)
Committee memberSvetlana Tomić (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2022-03-09, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract
Ciljevi istraživanja: Ispitati razliku u učestalosti nemotoričkih simptoma te u težini autonomnih i motoričkih simptoma između bolesnika s Parkinsonovom bolesti ranog početka i bolesnika s Parkinsonovom bolesti kasnog početka. Nacrt studije: Presječna studija. Ispitanici i metode: U istraživanju je sudjelovalo 53 bolesnika koji su se liječili od idiopatske Parkinsonove bolesti na Klinici za neurologiju u Kliničkom bolničkom centru Osijek. Za istraživanje je konstruiran upitnik gdje su se unosili podaci o dobi, spolu, dužini trajanja bolesti i dobi na početku pojave simptoma bolesti. Za procjenu težine motoričkih simptoma korišten je Unified Parkinson's Disease Rating Scale Part III (UPDRS III), za procjenu težine autonomnih simptoma korišten je Scales for Outcomes in Parkinson’s Disease – Autonomic Dysfunction (SCOPA-AUT), za procjenu učestalosti nemotoričkih simptoma korišten je Non-Motor Symptome Quest (NMSQ) i za procjenu težine stadija bolesti korišten je Hoehn and Yahr Scale (H&Y). Rezultati: Istraživanje je pokazalo da su bolesnici s Parkinsonovom bolesti ranog početka češće imali poremećaj kardiovaskularne funkcije (P = 0,007), prekomjernu dnevnu pospanost (P = 0,044) i promjene ponašanja tijekom REM faze sna (P = 0,041). Nije uočena razlika u dužini trajanja bolesti, spolnoj distribuciji, težini motoričkih simptoma i težini stadija bolesti između ispitivanih skupina. Zaključak: Bolesnici oboljeli od Parkinsonove bolesti ranog početka češće imaju poremećaj kardiovaskularne funkcije, prekomjernu dnevnu pospanost i promjene ponašanja tijekom REM faze sna.
Abstract (english)
Objectives: To examine the difference in the frequency of non-motor symptoms and in the severity of autonomic and motor symptoms between patients with young-onset Parkinson's disease and patients with late-onset Parkinson's disease. Study design: Cross-sectional study. Participants and methods: The study involved 53 patients treated for idiopathic Parkinson's disease at the Clinic of Neurology at the Clinical Hospital Center Osijek. A questionnaire was constructed for the research, where data on age, sex, duration of the disease and age at the beginning of the onset of disease symptoms were entered. Unified Parkinson's Disease Rating Scale Part III (UPDRS III) was used to assess the severity of motor symptoms, Scales for Outcomes in Parkinson’s Disease - Autonomic Dysfunction (SCOPA-AUT) was used to assess the severity of autonomic symptoms, Non-Motor Symptome Quest (NMSQ) was used to assess the frequency of non-motor symptoms, and Hoehn and Yahr Scale (H&Y) was used to assess the severity of the disease stages. Results: The study showed that patients with young-onset Parkinson's disease were more likely to have cardiovascular dysfunction (P = 0.007), excessive daytime sleepiness (P = 0.044), and REM sleep behaviour disorder (P = 0.041). No difference in disease duration, sexual distribution, severity of motor symptoms, and severity of disease stages was observed between the study groups. Conclusion: Patients with young-onset Parkinson's disease are more likely to have cardiovascular dysfunction, excessive daytime sleepiness, and REM sleep behaviour disorder.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:367533
Study programmeTitle: University Graduate Studies
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-04-28 12:09:04