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master's thesis
Ishodi testiranja neposredne i odgođene preosjetljivosti na jodne kontraste
2022. urn:nbn:hr:152:608820
Pastović, Magdalena
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Pastović, M. (2022). Ishodi testiranja neposredne i odgođene preosjetljivosti na jodne kontraste (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:608820

Pastović, Magdalena. "Ishodi testiranja neposredne i odgođene preosjetljivosti na jodne kontraste." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2022. https://urn.nsk.hr/urn:nbn:hr:152:608820

Pastović, Magdalena. "Ishodi testiranja neposredne i odgođene preosjetljivosti na jodne kontraste." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2022. https://urn.nsk.hr/urn:nbn:hr:152:608820

Pastović, M. (2022). 'Ishodi testiranja neposredne i odgođene preosjetljivosti na jodne kontraste', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 21 November 2024, https://urn.nsk.hr/urn:nbn:hr:152:608820

Pastović M. Ishodi testiranja neposredne i odgođene preosjetljivosti na jodne kontraste [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2022 [cited 2024 November 21] Available at: https://urn.nsk.hr/urn:nbn:hr:152:608820

M. Pastović, "Ishodi testiranja neposredne i odgođene preosjetljivosti na jodne kontraste", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:152:608820

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Metadata
TitleIshodi testiranja neposredne i odgođene preosjetljivosti na jodne kontraste
Title (english)Outcomes of testirang of immediate and delayed hypersensitivity to iodine contrast media
AuthorMagdalena Pastović
MentorSuzana Mimica (mentor)
Committee memberVlatka Periša (predsjednik povjerenstva)
Committee memberIvan Radoš (član povjerenstva)
Committee memberSuzana Mimica (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2022-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Pharmacology and Toxicology
Abstract
Cilj istraživanja: Cilj istraživanja bio je utvrditi postotak ispitanika s pozitivnim kožnim testom na jodna kontrastna sredstva te ispitati povezanost rezultata kožnih testova s težinom i karakteristika prethodne neželjene reakcije, vremenskim razmakom od reakcije, postojanjem preosjetljivosti na druge alergene, dobi, spolom i komorbiditetima. Nacrt studije: presječno istraživanje Ispitanici i metode: Ispitanici su bili pacijenti koji su podvrgnuti kožnim testovima na jodna kontrastna sredstva u Dnevnoj bolnici za kliničku farmakologiju Klinike za unutarnje bolesti KBC-a Osijek u razdoblju od početka siječnja 2017. godine do kraja prosinca 2021. godine. Ukupan broj ispitanika je 46. Podaci prikupljeni iz medicinske dokumentacije (demografski podaci, podaci o prethodnoj neželjenoj reakciji na jodno kontrastno sredstvo, preosjetljivost na druge alergene, komorbiditeti, preporuka za premedikaciju) su analizirani i uspoređivani. Rezultati: Nije zabilježen niti jedan prick test s pozitivnim ishodom. Najveći broj intradermalnih testova s pozitivnim ishodom buo je na Omnipaque 300. Povezanost je uočena između sljedećih varijabli: granično pozitivnog intradermalnog testa na Iomeron 400 i šećerne bolesti; granično pozitivnog intradermalnog testa na Ultravist 370 i preosjetljivosti na kontaktne alergene; spazma dišnih puteva i preporuke za premedikaciju. Između ostalih varijabli nije uočena značajna razlika. Zaključak: Ova presječna studija potvrdila je da su rezultati kožnog testiranja neposredne i odgođene preosjetljivosti na jodna kontrastna sredstva većinom negativni. Unatoč tome, premedikacija je preporučena kao mjera prevencije svim ispitanicima koji su imali težu prethodnu neželjenu reakciju, čak i ako kožni testovi nisu potvrdili postojanje preosjetljivosti jer negativni kožni testovi ne isključuju mogućnost pseudoalergijske reakcije.
Abstract (english)
Objectives: The aim of the study was to evaluate the percentage of subjects with a positive skin test for iodine contrast media and to examine the relationship between skin test results and severity and characteristics of previous adverse reactions, time interval from reaction, hypersensitivity to other allergens, age, sex and comorbidities. Study design: The study was conducted as a cross-sectional study. Subjects and methods: The subjects were patients who underwent skin tests for iodine contrast media in Clinical Pharmacology outpatient clinic at the Clinic for Internal Diseases as a part of University Hospital Center Osijek, in the period from January 2017 to the end of December 2021. The total number of subjects was 46. Data collected from medical records (demographic data, data on previous adverse reactions to iodine contrast media, hypersensitivity to other allergens, comorbidities, recommendation for premedication) were analyzed and compared. Results: No prick test with a positive outcome was observed. The largest number of intradermal tests with a positive outcome was for Omnipaque 300. An association between the following variables was observed: borderline positive intradermal test for Iomeron 400 and diabetes mellitus; borderline positive intradermal test for Ultravist 370 and hypersensitivity to contact allergens; airway spasm and premedication recommendations. No significant difference was observed between the other variables. Conclusion: This cross-sectional study confirmed that the results of skin testing for immediate and delayed hypersensitivity to iodine contrast media are mostly negative. Nevertheless, premedication was recommended as a prevention measure to all subjects who had a severe previous adverse reaction, even if skin tests did not confirm the existence of hypersensitivity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:608820
Study programmeTitle: University Graduate Studies
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2023-06-09 12:14:43