Objectives: The aim of study was to examine the frequency and technique of CT-guided percutaneous transthoracic sampling of suspicious pulmonary lesions, to examine the frequency, type and outcomes of post-interventional complications, to examine the frequency of obtaining adequate samples, and to examine whether there are differences in the outcome of CT-guided PTNB with regard to demographic and clinical characteristics patients and sampling technique. Study Design: Cross - sectional survey with historical data. Participants and methods: The study has included patients who underwent transthoracic CT - guided percutaneous sampling of pulmonary lesions at the Department of Diagnostic and Interventional Radiology of the Osijek Clinical Hospital Center during 2022. Results: The study included 202 patients, with median age of 67 years, ranging from 27 to 85 years. 86 (42.6 %) subjects had emphysema, and 48 (23.8 %) subjects had a lesion localized in the right upper lobe. Most often, the procedure was performed with a median needle thickness of 20 G. The most frequent positioning was prone in 83 (41.1 %) patients. Pneumothorax as a complication of the procedure was noted in 67 (33.2 %) patients, and perilesional hemorrhage in 50 (24.8 %) patients. The most frequent cytological and pathohistological diagnosis in 43 (21.3 %) patients was SCLC. Conclusion: Most subjects had lesion localized in the right upper lobe, with a procedure performed with a 20 G needle, with patient in prone positioning technique. The most common complications of the procedure were pneumothorax and hemorrhage, and the most common cytological and pathohistological diagnosis is SCLC. There were no significant differences in complications of CT - PTNB related to the demographic and clinical characteristics of the patients, but there was a difference regarding the lesion size.