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master's thesis
Utjecaj HLA podudarnosti primatelja i darivatelja bubrega na ishod transplantacije bubrega u Kliničkom bolničkom centru Osijek
2023. urn:nbn:hr:152:262930
Sabljo, Roberta
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Sabljo, R. (2023). Utjecaj HLA podudarnosti primatelja i darivatelja bubrega na ishod transplantacije bubrega u Kliničkom bolničkom centru Osijek (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:262930

Sabljo, Roberta. "Utjecaj HLA podudarnosti primatelja i darivatelja bubrega na ishod transplantacije bubrega u Kliničkom bolničkom centru Osijek." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2023. https://urn.nsk.hr/urn:nbn:hr:152:262930

Sabljo, Roberta. "Utjecaj HLA podudarnosti primatelja i darivatelja bubrega na ishod transplantacije bubrega u Kliničkom bolničkom centru Osijek." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2023. https://urn.nsk.hr/urn:nbn:hr:152:262930

Sabljo, R. (2023). 'Utjecaj HLA podudarnosti primatelja i darivatelja bubrega na ishod transplantacije bubrega u Kliničkom bolničkom centru Osijek', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 10 December 2024, https://urn.nsk.hr/urn:nbn:hr:152:262930

Sabljo R. Utjecaj HLA podudarnosti primatelja i darivatelja bubrega na ishod transplantacije bubrega u Kliničkom bolničkom centru Osijek [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2023 [cited 2024 December 10] Available at: https://urn.nsk.hr/urn:nbn:hr:152:262930

R. Sabljo, "Utjecaj HLA podudarnosti primatelja i darivatelja bubrega na ishod transplantacije bubrega u Kliničkom bolničkom centru Osijek", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:152:262930

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TitleUtjecaj HLA podudarnosti primatelja i darivatelja bubrega na ishod transplantacije bubrega u Kliničkom bolničkom centru Osijek
Title (english)The influence of recipient and kidney HLA mismatch on the outcomes of kidney transplantation in University Hospital Centre Osijek
AuthorRoberta Sabljo
MentorTihana Šimundić (mentor)
Committee memberDubravka Mihaljević (predsjednik povjerenstva)
Committee memberVlatka Periša (član povjerenstva)
Committee memberTihana Šimundić (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2023-09-28, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract
Cilj istraživanja: Istražiti utjecaj molekula HLA-A, HLA-B i HLA-DR te ukupnog MM (engl. mismatch) na ishod transplantacije bubrega. Nacrt studije: Studija je formirana kao presječno istraživanje. Ispitanici i metode: U istraživanje je uključen 81 bolesnik kojima je bubrežni presadak transplantiran u Kliničkom bolničkom centru Osijek. Podatci o primateljima presatka pribavljeni su iz medicinske dokumentacije i bolničkog informatičkog sustava (BIS), dok su podatci o darivateljima presatka i HLA podudaranosti dobiveni iz baze Eurotransplantant. Podatci su statistički obrađeni pomoću MedCalc® Statistical Software (version 20.100) i SPSS (version 23). Rezultati: U skupini primatelja medijan dobi bio je 60 (55-66) godina, a medijan dobi darivatelja bubrega iznosio je 48 (40-57) godine. Prema Kruskal Wallis testu nije pokazana povezanost ukupnog MM (0-6), HLA-B (0-2), HLA-DR (0-2) te 1 i 2 podudaranosti u A lokusu HLA s vrijednostima kreatinina u nijednoj godini nakon transplantacije, kao ni sa vrijednostima EGFR. Iznimka je 0 podudaranosti u A lokusu HLA koja je povezana sa značajno povišenim vrijednostima kreatinina u svakoj godini. Zaključak: 0 podudaranosti u HLA-A lokusu jedino je bilo povezano s visokim razinama kreatinina u svakoj godini bez utjecaja na vrijednosti EGFR, dok ukupni MM,1 i 2 podudaranosti u HLA-A, HLA-B i HLA-DR nisu bili značajno povezani s razinama kreatinina i EGFR.
Abstract (english)
Objecitives: To examine the influence of HLA-A, HLA-B and HLA-DR molecules and overall MM (mismatch) on the outcome of kidney transplantation. Study design: The study is formed as a cross-sectionalstudy. Participants and methods: The study included 81 patients who received a kidney transplant at the Clinical Medical Center Osijek. Data on transplant recipients were obtained from medical records and the hospital information system (BIS), while data on transplant donors and HLA matching were obtained from the Eurotransplantant database. Data were statistically processed using MedCalc® Statistical Software (version 20.100) and SPSS (version 23). Results: In the recipient group, the median age was 60 (55-66), and the median age of kidney donors was 48 (40-57). According to the Kruskal Wallis test, no association of total MM (0- 6), HLA-B (0-2), HLA-DR (0-2) and 1 and 2 matches in the A locus of HLA was shown with creatinine levels in any year after transplantation, nor with EGFR values. An exception is 0 matches in the A locus of HLA, which is associated with significantly higher creatinine levels in each year. Conclusion: 0 matching in the HLA-A locus was the only one associated with higher creatinine levels in each year without affecting EGFR values, while total MM, 1 and 2 matching in HLA-A, HLA-B and HLA-DR were not significantly associated with levels of creatinine and EGFR.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:262930
Study programmeTitle: University graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra medicinsko laboratorijske dijagnostike (magistar/magistra medicinsko laboratorijske dijagnostike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-04-05 10:11:16