| Abstract | CILJEVI ISTRAŽIVANJA: Prevesti na hrvatski jezik i validirati upitnik o kvaliteti života bolesnika s laringofaringealnim refluksom (LPR-HRQL). Ispitati može li se LPR-HRQL upitnik koristiti kao jednostavna metoda procjene kvalitete života bolesnika s laringofaringealnim refluksom (LPR). Ispitati utjecaj prehrane na nastanak, tijek bolesti te kvalitetu života bolesnika s LPR-om.
NACRT STUDIJE: Istraživanje je ustrojeno kao kontrolirani nerandomizirani klinički pokus u kojem su izvor podataka bili rezultati modificiranog Food Frequeny Questionnaire (FFQ), 36-Item Short Form Health Survey (SF-36) i LPR-HRQL upitnika. Svi ispitanici su praćeni kroz 60 dana nakon postavljanja dijagnoze LPR-a.
ISPITANICI I METODE: U istraživanje je uključeno 100 ispitanika s LPR-om i 65 ispitanika kontrolne skupine. Skupina ispitanika s LPR-om je dodatno nasumično podjeljena u dvije podskupine. Prva podskupina je liječena esomeprazolom u dvokratnoj dnevnoj dozi od 20 mg te higijensko – dijetetskim mjerama, a druga pantoprazolom u dvokratnoj dnevnoj dozi od 20 mg te higijensko – dijetetskim mjerama. Ispitanici su ispunili LPR-HRQL, SF-36 i FFQ upitnike odmah nakon inicijalnog pregleda te nakon 30 i 60 dana provođenja liječenja.
REZULTATI: Preveden na hrvatski jezik, LPR-HRQL upitnik je razumljiv, ima dobra psihometrijska svojstva (pouzdanost i valjanost) u hrvatskoj kulturološkoj sredini i može se koristiti za procjenu kvalitetu života oboljelih od LPR-a. Bolesnici s LPR-om konzumiraju više hrane visokoga refluksogenog potencijala te piju više gaziranih pića i sokova te imaju lošiju kvalitetu života u odnosu na kontrolnu skupinu. Inhibitori protonske pumpe (IPP) u dvokratnoj dnevnoj dozi od 20 mg uz promjenu prehrambenih navika znatno smanjuju simptome LPR-a te povećavaju kvalitetu života.
ZAKLJUČAK: LPR-HRQL upitnik je dobar alat za procjenu kvalitete života oboljelih od LPR-a. Izbjegavanje hrane visokog refluksogenog potencijala (kisela, slatka, začinjena hrana i gazirana pića) uz uvođenje hrane niskog refluksogenog potencijala i vode u kombinaciji s IPP znatno smanjuje simptome i kliničke znakove LPR-a te poboljšava kvalitetu života. |
| Abstract (english) | OBJECTIVES: This study aimed to translate and validate the Laryngopharyngeal Reflux Health-Related Quality of Life (LPR-HRQL) questionnaire in Croatian. Additionally, it assessed the suitability of the LPR-HRQL questionnaire for evaluating the quality of life in laryngopharyngeal reflux (LPR) patients and explored the impact of dietary habits on the disease progression and patients quality of life.
STUDY DESIGN: A controlled, non-randomized clinical trial design was used, employing data from the modified Food Frequency Questionnaire (FFQ), 36-Item Short Form Health Survey (SF-36), and LPR-HRQL questionnaire. The study followed 100 LPR subjects over a 60-day period post-diagnosis.
PARTICIPITANS AND METHODS: There was a total of 100 subjects with LPR and 65 subjects in the control group. Among the LPR subjects, two subgroups were formed randomly: one treated with esomeprazole (20 mg, twice daily) and hygienic-dietary measures, and the other with pantoprazole (20 mg, twice daily) and hygienic-dietary measures. Participants filled out FFQ-m, SF-36, and LPR-HRQL questionnaires post-initial examination and during control assessments at 30 and 60 days.
RESULTS: The translated Croatian version of the LPR-HRQL questionnaire demonstrated strong psychometric properties (reliability and validity) within the Croatian cultural context. It proved effective in evaluating LPR patients quality of life. Patients with LPR exhibited higher consumption of foods with high reflux potential, carbonated beverages, and juices, resulting in a lower quality of life compared to the control group. Administering proton pump inhibitors (20 mg, twice daily) alongside dietary adjustments significantly alleviated LPR symptoms and enhanced quality of life.
CONCLUSION: The LPR-HRQL questionnaire effectively measures the quality of life for LPR patients. By avoiding foods with high reflux potential, such as acidic, sweet, and spicy items, and integrating proton pump inhibitors with dietary changes, symptom severity decreased and patients quality of life improved. |
