| Abstract | Cilj istraživanja: Ispitati povezanost između vrijednosti Ki 67 s metastazama u limfne čvorove,
imunofenotipom karcinoma dojke, dobi, veličinom tumora, histološkim podtipom,
limfovaskularnom invazijom i in situ komponentom.
Nacrt studije: presječno istraživanje
Ispitanici i metode: U istraživanju su prikupljeni patohistološki nalazi pacijenata oboljelih od
karcinoma dojke koji su liječeni u KBC-u Osijek u razdoblju od početka 2022. do kraja 2023.
godine, a ukupan broj pacijenata bio je 480. Za statističku obradu podataka korišten je ꭓ² test,
Shapiro - Wilkovim test i metoda ROC krivulje.
Rezultati: U istraživanju je 84 % bolesnica bilo starije od 50 godina, a prema histološkom tipu 76
% je imalo NOS – invazivni karcinom dojke. S obzirom na imunofenotip najviše je bilo luminalnih
B karcinoma. Uz vrijednosti Ki 67 od 50 % i više povezuju se učestalije HER2 pozitivni i trostruko
negativni karcinomi, T3 i T4 stadij bolesti prema TNM klasifikaciji i prisutnost metastaza u limfne
čvorove (N1, N2, N3). Nisu postojale razlike u prisutnosti in situ komponente i dobi bolesnica u
odnosu na vrijednosti Ki 67.
Zaključak: Vrijednosti Ki 67 50 % i više povezuju se s većom zahvaćenosti limfnih čvorova i
agresivnijim oblicima karcinoma, kao što su HER2 pozitivni i trostruko negativni. Cut-off
vrijednost Ki 67 za metastaze u limfne čvorove bila je 26 % i ona označava vrijednost od koje se
povećava broj pozitivnih limfnih čvorova. |
| Abstract (english) | Association between Ki 67 proliferation index and axillary lymph node metastasis in breast
cancer
Objectives: Examine the correlation between Ki 67 values and lymph node metastases,
immunophenotype of breast cancer, age, tumor size, histological subtype, lymphovascular
invasion, and in situ component.
Study design: cross-sectional study
Participants and methods: The study collected pathological reports of patients with breast cancer
treated at the University Hospital Center Osijek from the beginning of 2022 to the end of 2023,
with a total number of patients being 480. The ꭓ² test, the Shapiro-Wilk test, and the ROC curve
method were used for statistical analysis.
Results: In the study, 84 % of the patients were older than 50 years, and according to histological
type, 76 % had NOS invasive breast carcinoma. Regarding immunophenotype, luminal B
carcinomas were the most prevalent. Ki-67 values of 50 % and higher were associated with more
frequent HER2-positive and triple-negative carcinomas, T3 and T4 stages of disease according to
TNM classification, and the presence of lymph node metastases (N1, N2, N3). There were no
differences in the presence of in situ components and patient age relative to Ki-67 values.
Conclusion: Ki-67 values of 50 % and higher are associated with greater lymph node involvement
and more aggressive forms of carcinoma, such as HER2-positive and triple-negative cancers. The
cut-off value of Ki-67 for lymph node metastases was 26 %, which indicates the value from which
the number of positive lymph nodes increases. |
