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master's thesis
Meta analiza uspješnosti postupka umreževanja kolagena u liječenju keratokonusa
2024. urn:nbn:hr:152:346642
Herega, Ivan
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Herega, I. (2024). Meta analiza uspješnosti postupka umreževanja kolagena u liječenju keratokonusa (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:346642

Herega, Ivan. "Meta analiza uspješnosti postupka umreževanja kolagena u liječenju keratokonusa." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2024. https://urn.nsk.hr/urn:nbn:hr:152:346642

Herega, Ivan. "Meta analiza uspješnosti postupka umreževanja kolagena u liječenju keratokonusa." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2024. https://urn.nsk.hr/urn:nbn:hr:152:346642

Herega, I. (2024). 'Meta analiza uspješnosti postupka umreževanja kolagena u liječenju keratokonusa', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 20 November 2024, https://urn.nsk.hr/urn:nbn:hr:152:346642

Herega I. Meta analiza uspješnosti postupka umreževanja kolagena u liječenju keratokonusa [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2024 [cited 2024 November 20] Available at: https://urn.nsk.hr/urn:nbn:hr:152:346642

I. Herega, "Meta analiza uspješnosti postupka umreževanja kolagena u liječenju keratokonusa", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:152:346642

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Metadata
TitleMeta analiza uspješnosti postupka umreževanja kolagena u liječenju keratokonusa
Title (english)Meta-analysis of the efficacy of the collagen cross-linking procedure in the treatment of keratoconus
AuthorIvan Herega
MentorDubravka Biuk (mentor)
Committee memberSuzana Matić (predsjednik povjerenstva)
Committee memberKrešimir Šolić (član povjerenstva)
Committee memberDubravka Biuk (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2024-09-23, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract
Cilj istraživanja: Sažeti podatke iz uključenih studija i dati preporuku koju metodu (SCXL ili TCXL) koristiti za liječenje KC-a. Ustroj studije. Sustavno istraživanje i meta-analiza. Materijal i metode: Pretražene su baze podataka PubMed i Google Scholar s ključnim riječima. Kriterij za uključivanje studije je RCT koji uključuje usporedbu ishoda učinkovitosti i sigurnosti SCXL-a s TCXL-om dvanaest mjeseci nakon zahvata kod pacijenata oboljelih s KC-om. Rezultati: Uključeno je sedam studija s ukupno 360 ispitanika i 424 oka. Postojala je značajna razlika u Kmax-u (P = 0,04) i CYL-u (P = 0,02) u korist SCXL-a. Postojala je značajna razlika u TCT-u između dviju skupina (P < 0,001) u korist TCXL-a, nadalje TCXL je imao bolji sigurnosni profil. Za UCVA, BCVA, MRSE i GES nisu zabilježene značajne razlike. Zaključak: Meta-analiza pokazuje da su SCXL i TCXL metode obje učinkovite u usporavanju i zaustavljanju napredovanja KC-a. SCXL ima prednost prema TCXL-u, no zbog heterogenosti studija i drugih nedostataka to se sa sigurnošću ne može potvrditi. Potrebno je više standardiziranih RCT-ova s duljim razdobljem praćenja radi postizanja kvalitetnijih dokaza.
Abstract (english)
Objectives: To summarize data from the included studies and provide a recommendation on which method (SCXL or TCXL) should be used for the treatment of KC. Study Design: Systematic review and meta-analysis. Materials and Methods: The databases PubMed and Google Scholar were searched with keywords. The inclusion criteria for studies was RCT that compare the outcomes of the efficacy and safety of SCXL versus TCXL twelve months after the procedure in patients with KC. Results: Seven studies were included with a total of 360 participants and 424 eyes. There was a significant difference in Kmax (P = 0,04) and CYL (P = 0,02) favoring SCXL. There was a significant difference in TCT between the two groups (P < 0,001) favoring TCXL, furthermore TCXL had a better safety profile. No significant differences were observed for UCVA, BCVA, MRSE and GES. Conclusion: The meta-analysis shows that both SCXL and TCXL methods are effective in slowing and halting the progression of KC. SCXL has an advantage over TCXL, but due to the heterogeneity of studies and other limitations, this cannot be confirmed with certainty. More standardized RCTs with longer follow-up periods are needed to achieve higher quality evidence.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:346642
Study programmeTitle: University Graduate Studies
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-10-30 07:40:37