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POVEZANOST SERUMSKE AKTIVNOSTI KALPAINA 1 I KONCENTRACIJE INTERLEUKINA 33 S RAZVOJEM AKUTNOG RESPIRATORNOG DISTRES SINDROMA U BOLESNIKA S PNEUMONIJOM UZROKOVANOM SARS-CoV-2 VIRUSOM
2024. urn:nbn:hr:152:493423
Loinjak, Domagoj
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

Cite this document

Loinjak, D. (2024). POVEZANOST SERUMSKE AKTIVNOSTI KALPAINA 1 I KONCENTRACIJE INTERLEUKINA 33 S RAZVOJEM AKUTNOG RESPIRATORNOG DISTRES SINDROMA U BOLESNIKA S PNEUMONIJOM UZROKOVANOM SARS-CoV-2 VIRUSOM (Doctoral thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:493423

Loinjak, Domagoj. "POVEZANOST SERUMSKE AKTIVNOSTI KALPAINA 1 I KONCENTRACIJE INTERLEUKINA 33 S RAZVOJEM AKUTNOG RESPIRATORNOG DISTRES SINDROMA U BOLESNIKA S PNEUMONIJOM UZROKOVANOM SARS-CoV-2 VIRUSOM." Doctoral thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2024. https://urn.nsk.hr/urn:nbn:hr:152:493423

Loinjak, Domagoj. "POVEZANOST SERUMSKE AKTIVNOSTI KALPAINA 1 I KONCENTRACIJE INTERLEUKINA 33 S RAZVOJEM AKUTNOG RESPIRATORNOG DISTRES SINDROMA U BOLESNIKA S PNEUMONIJOM UZROKOVANOM SARS-CoV-2 VIRUSOM." Doctoral thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2024. https://urn.nsk.hr/urn:nbn:hr:152:493423

Loinjak, D. (2024). 'POVEZANOST SERUMSKE AKTIVNOSTI KALPAINA 1 I KONCENTRACIJE INTERLEUKINA 33 S RAZVOJEM AKUTNOG RESPIRATORNOG DISTRES SINDROMA U BOLESNIKA S PNEUMONIJOM UZROKOVANOM SARS-CoV-2 VIRUSOM', Doctoral thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 19 December 2024, https://urn.nsk.hr/urn:nbn:hr:152:493423

Loinjak D. POVEZANOST SERUMSKE AKTIVNOSTI KALPAINA 1 I KONCENTRACIJE INTERLEUKINA 33 S RAZVOJEM AKUTNOG RESPIRATORNOG DISTRES SINDROMA U BOLESNIKA S PNEUMONIJOM UZROKOVANOM SARS-CoV-2 VIRUSOM [Doctoral thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2024 [cited 2024 December 19] Available at: https://urn.nsk.hr/urn:nbn:hr:152:493423

D. Loinjak, "POVEZANOST SERUMSKE AKTIVNOSTI KALPAINA 1 I KONCENTRACIJE INTERLEUKINA 33 S RAZVOJEM AKUTNOG RESPIRATORNOG DISTRES SINDROMA U BOLESNIKA S PNEUMONIJOM UZROKOVANOM SARS-CoV-2 VIRUSOM", Doctoral thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:152:493423

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TitlePOVEZANOST SERUMSKE AKTIVNOSTI KALPAINA 1 I KONCENTRACIJE INTERLEUKINA 33 S RAZVOJEM AKUTNOG RESPIRATORNOG DISTRES SINDROMA U BOLESNIKA S PNEUMONIJOM UZROKOVANOM SARS-CoV-2 VIRUSOM
Title (english)THE CORRELATION OF SERUM CALPAIN 1 ACTIVITY AND CONCENTRATIONS OF INTERLEUKIN 33 WITH DEVELOPMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME IN PATIENTS WITH SARS-COV-2 VIRUS INDUCED PNEUMONIA
AuthorDomagoj Loinjak
MentorRobert Smolić (mentor)
Committee memberLjiljana Perić (predsjednik povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2024, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Universal decimal classification
(UDC)		61 - Medical sciences
Abstract
Cilj istraživanja. Glavni cilj provedenog istraživanja bio je ispitati odnos serumskih vrijednosti aktivnosti kalpaina 1 i koncentracije IL-33 kod bolesnikâ s COVID-19 pneumonijom koji su razvili ARDS te ih usporediti s vrijednostima bolesnika s COVID-19 pneumonijom koji nisu razvili ARDS, markerima akutnog upalnog odgovora te primjenom oksigenoterapije i mehaničke ventilacije. Ustroj istraživanja. Istraživanje je postavljeno kao istraživanje parova (engl. casecontrol study). Ispitanici i metode. U istraživanje je uključeno 80 ispitanika s potvrđenom COVID19 pneumonijom, a koji su podijeljeni u dvije skupine: ispitivana skupina – ispitanici koji su razvili ARDS (40 ispitanika) i kontrolna skupina – ispitanici koji nisu razvili ARDS (40 ispitanika). Metodologija istraživanja uključivala je prikupljanje kliničkih podataka i parametara o ispitanicima, uzorkovanja krvi te laboratorijskih analiza. Aktivnost kalpaina 1 određena je fluorimetrijskom metodom, dok je koncentracija određena IL-33 ELISA metodom (engl. Enzyme-Linked Immunosorbent Assay), pri čemu su korišteni komercijalno dostupni kitovi. Rezultati. Serumske vrijednosti aktivnosti kalpaina 1 i koncentracije IL-33 kod ispitanika oboljelih od COVID-19 pneumonije, a koji su razvili ARDS (ispitivana skupina) međusobno su bile povezane, odnosno kako je rasla aktivnost kalpaina 1, rasla je i koncentracija IL-33 te su one bile značajno više, nego kod ispitanika koji nisu razvili ARDS (kontrolna skupina). Također, serumske vrijednosti aktivnosti kalpaina 1 i koncentracije IL-33 pozitivno su korelirale s markerima akutnog upalnog odgovora te primjenom mehaničke ventilacije. Zaključak. Na temelju dobivenih rezultata može se zaključiti da aktivnost kalpaina 1 i koncentracije IL-33 u serumu ima značaj u nastanku i razvoju ARDS-a kod bolesnikâ s COVID-19 pneumonijom.
Abstract (english)
Objectives. The main aim of the research was to examine the relationship between the serum values of calpain 1 activity and the IL-33 concentration in patients with COVID-19 pneumonia who developed ARDS, and to compare them with the values of patients with COVID-19 pneumonia who did not develop ARDS, the markers of acute inflammatory response and the usage of oxygenotherapy or mechanical ventilation. Study design. The research is structured as a case-control study. Participants and methods. The study included 80 adult subjects with confirmed COVID-19 pneumonia, and who were divided into two groups: the examined group - subjects who developed ARDS (40 subjects) and the control group - subjects who did not develop ARDS (40 subjects). The methodology included collecting clinical data and parameters about the subjects, blood sampling and laboratory analyses. The activity of calpain 1 was determined by the fluorimetric method, while the IL-33 concentration was determined by the ELISA method (Enzyme-Linked Immunosorbent Assay), using commercially available kits. Results. The serum values of calpain 1 activity and IL-33 concentration in subjects with COVID-19 pneumonia who developed ARDS (examined group) were interconnected, i.e. as the calpain 1 activity increased, so did the IL-33 concentration, and they were significantly higher than in subjects who did not develop ARDS (the control group). Also, the serum values of calpain 1 activity and IL-33 concentration positively correlated with the markers of acute inflammatory response and the use of mechanical ventilation. Conclusion. Based on the obtained results, it can be concluded that the calpain 1 activity and the concentration of IL-33 in the serum have significance in the occurrence and the development of ARDS in patients with COVID-19 pneumonia.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:493423
Promotion2024
Study programmeTitle: University Postgraduate Study
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-12-19 08:01:00