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undergraduate thesis
Učestalost alelne varijante HLA-DRB1*08 kod oboljelih od juvenilnog idiopatskog artritisa u populaciji istočne Hrvatske
2016. urn:nbn:hr:152:877392
Vuković, Stela
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Vuković, S. (2016). Učestalost alelne varijante HLA-DRB1*08 kod oboljelih od juvenilnog idiopatskog artritisa u populaciji istočne Hrvatske (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:877392

Vuković, Stela. "Učestalost alelne varijante HLA-DRB1*08 kod oboljelih od juvenilnog idiopatskog artritisa u populaciji istočne Hrvatske." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2016. https://urn.nsk.hr/urn:nbn:hr:152:877392

Vuković, Stela. "Učestalost alelne varijante HLA-DRB1*08 kod oboljelih od juvenilnog idiopatskog artritisa u populaciji istočne Hrvatske." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2016. https://urn.nsk.hr/urn:nbn:hr:152:877392

Vuković, S. (2016). 'Učestalost alelne varijante HLA-DRB1*08 kod oboljelih od juvenilnog idiopatskog artritisa u populaciji istočne Hrvatske', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 11 December 2024, https://urn.nsk.hr/urn:nbn:hr:152:877392

Vuković S. Učestalost alelne varijante HLA-DRB1*08 kod oboljelih od juvenilnog idiopatskog artritisa u populaciji istočne Hrvatske [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2016 [cited 2024 December 11] Available at: https://urn.nsk.hr/urn:nbn:hr:152:877392

S. Vuković, "Učestalost alelne varijante HLA-DRB1*08 kod oboljelih od juvenilnog idiopatskog artritisa u populaciji istočne Hrvatske", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:152:877392

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Metadata
TitleUčestalost alelne varijante HLA-DRB1*08 kod oboljelih od juvenilnog idiopatskog artritisa u populaciji istočne Hrvatske
Title (english)Frequency of the HLA-DRB1*08 in JIA population of Eastern Croatia
AuthorStela Vuković
MentorSaška Marczi (mentor)
Committee memberSaška Marczi (predsjednik povjerenstva)
Committee memberLjubica Glavaš-Obrovac (član povjerenstva)
Committee memberMarija Heffer (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2016-09-08, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Biochemistry
Abstract
Cilj istraživanja: Odrediti učestalost alelne varijante HLA-DRB1*08 u oboljelih od juvenilnog idiopatskog artritisa (JIA) u populaciji istočne Hrvatske; usporediti alelnu frekvenciju HLA-DRB1*08 u skupini ispitanika s ranije objavljenim podatkom alelne frekvencije u kontrolnoj skupini. U skupini oboljelih od JIA usporediti učestalost alela HLA-DRB1*08 sa pojavnošću pridruženih autoimunih bolesti te s pojavom JIA ili drugih autoimunih bolesti u obiteljskoj anamnezi. Ispitanici i metode: Rad obuhvaća skupinu ispitanika od 66 bolesnika (46 ženskog spola, 20 muškog spola) s postavljenom dijagnozom JIA kojima je molekularna tipizacija HLA učinjena u rutinskoj dijagnostici KBC-a Osijek. Kontrolnu skupinu predstavljali su ranije objavljeni rezultati molekularne tipizacije HLA 210 zdravih nesrodnih ispitanika iz opće populacije Hrvatske. Rezultati: Alel HLA-DRB1*08 s povišenom je učestalošću (AF = 5,3%) bio zastupljen u oboljelih od JIA u odnosu na kontrolnu skupinu (AF = 3,9%). U podskupini oboljelih od oligoartritisa također je zabilježena povećana učestalost alela HLA-DRB1*08 (AF = 10,0%) kako u odnosu na kontrolnu skupinu tako i u odnosu na ostale JIA podskupine. Ni jedan od dobijenih rezultata nije dostigao statistički značajnu razinu. Zaključak: Povećana učestalost alela HLA-DRB1*08 u oboljelih od JIA u populaciji istočne Hrvatske, te povećana učestalost tog alela u podskupini oligoartritisa u skladu je s literaturnim podacima o pozitivnoj povezanosti JIA, te oligoartikularnog oblika JIA, s alelom HLA-DRB1*08. U ispitivanoj skupini JIA pacijenata i ispitivanim podskupinama nije uočena povezanost između HLA-DRB1*08 i pridruženih autoimunih bolesti, te pojave drugih autoimunih bolesti u obiteljskoj anamnezi.
Abstract (english)
Objectives: Determine the HLA-DRB1*08 allele frequency in the population of Eastern Croatia suffering from juvenile idiopathic arthritis (JIA). Afterwards, compare the HLA-DRB1*08 allele frequency of the research subjects with the previously published allele frequency (AF) data in the control group. Compare the frequency of HLA-DRB1*08 with presence of JIA associated autoimmune diseases and with family history of autoimmunity. Patients and methods: The research subject group consisted of 66 patients (46 female, 20 male) diagnosed with JIA. Their molecular HLA typing was performed during routine diagnostics at the University Hospital Osijek. Previously published results of molecular HLA typing of 210 healthy, unrelated individuals from the general population of Croatia were the control group in this research. Results: The final results show that the appearance of the DRB1*08 allele in patients suffering from JIA was found. The increased frequency of HLA-DRB1*08 allele was found in JIA patients cohort (AF = 5,3%) vs control group (AF = 3,9%). After stratification of JIA group into subgroups (oligoarthritis, monoarthritis, polyarthritis), the largest AF of 10% was recorded in the oligoarthritis subgroup. None of the results had a significant statistical impact. Conclusion: The increased frequency of HLA-DRB1*08 allele in JIA cohort of Eastern Croatia population and increased frequency in olygoarticular JIA subgroup are in accordance with research results indicating HLA-DRB1*08 association to JIA susceptibility in other populations. In the research subject group and the control group, a connection among HLA-DRB1*08 and associated autoimmune diseases as well as the appereance of other autoimmune diseases in the family anamnesis was not found.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:877392
Study programmeTitle: University undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni prvostupnik/prvostupnica (baccalaureus/baccalaurea) sestrinstva (sveučilišni prvostupnik/prvostupnica (baccalaureus/baccalaurea) sestrinstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2017-03-31 09:29:51