OBJECTIVES. Quality of life (Qol) has become an important aspect of modern medicine. Nasal obstruction caused by a deformed septum is a common reason for visiting a doctor and undergoing septoplasty. To evaluate the effectiveness of septoplasty, this study relied on subjective impressions of the patient's own health collected by analyzing the Sino-Nasal Outcome Test 22 (SNOT 22) and objective rhinomanometric examination. STUDY DESIGN. Prospective study. PARTICIPANTS AND METHODS. The study included 22 patients with nasal deformation, (median age 31.5 years) and 22 control patients without nose breathing problems (median age 33 years) during the period from December 2016 to June 2017 at the Clinic for Otorhinolaryngology and Head and Neck Surgery at the Clinical hospital Center of Osijek (KBCO). 22 symptoms from the questionnaire were taken into account and also total resistance and total flow obtained by rinomanometry, before and after surgery. The data was statistically processed using SPSS. RESULTS. Mean value of SNOT 22 test in case group improved 1 month postoperatively from 41,5 (22,5 – 57,8) to 15 (7,8 – 22,8), however the level of the control group was not reached. Statistical significance occurred in 10 out of 22 symptoms related to nose pain and sleep quality. Nasal congestion was a primary health problem for 96 % of the preoperative subjects. Total resistance after surgery decreased, and total air flow increased, although there was no correlation with the SNOT 22 score. CONCLUSION. Septoplasty reduces health problems, especially those related to nose function and improves the quality of life. Rhinomanometry is very useful for preoperative evaluation of whether the patient should undergo septoplasty or not.