| Abstract | Cilj istraživanja bio je utvrditi utjecaj biološke terapije na kvalitetu života bolesnika oboljelih od upalnih bolesti crijeva. Ispitanici i metode. Ispitivanje je obuhvatilo 63 bolesnika s endoskopski potvrđenom dijagnozom ulceroznog kolitisa i Crohnove bolesti. Instrument istraživanja bio je anketni upitnik koji se sastojao od 18 pitanja. Razlike kategorijskih varijabli testirane su 2 testom, a po potrebi Fisherovim egzaktnim testom. Razina značajnosti je postavljena na α = 0,05. Rezultati. Značajno je više ispitanika s ulceroznim kolitisom bez biološke terapije u odnosu na Crohnovu bolest s biološkom terapijom (Fisherov egzaktni test, p=0,007). Uz slabokrvnost kao posljedicu krvarenja, fistule su najčešća komplikacija, odnosno fistula je značajno više kod ispitanika na biološkoj terapiji (Fisherov egzaktni test, p=0,007), dok je krvarenje značajno prisutno kod 11 (61,1%) ispitanika bez biološke terapije. Da najbolje razumiju utjecaj njihove bolesti na kvalitetu života, liječnike gastroenterologe navodi 46 (73%) ispitanika, a njih 23 (36,5%) medicinske sestre gastroenterološkog odjela, značajno više, njih 20 (44,4%) koji primaju biološku terapiju (Fisherov egzaktni test, p=0,047). Ovi podatci su i razlog zbog kojih značajno više ispitanika koji su na biološkoj terapiji, njih 29 (70,7%) su upućeni u način, tijek i moguće komplikacije biološke terapije (2 test, p=0,017). Ispitanici su svoje zadovoljstvo kvalitetom života, od kada su na biološkoj terapiji, ocijenili na skali ocjenom 8 u rasponu od 4 do 10. Zaključak. Nakon provedene ankete i statističke obrade podataka može se zaključiti da su ispitanici zadovoljni rezultatima biološke terapije i radom zdravstvenih djelatnika uključenog u primjenu ove terapije. |
| Abstract (english) | The aim of this study was to determine the influence of biological therapy on the quality of life of patients with IBD. Patients and methods. The study involved 63 patients with an endoscopically confirmed diagnosis of ulcerative colitis and Crohn's disease. The survey instrument was a questionnaire which consisted of 18 questions. The differences in categorical variable were tested with an 2 test and, if necessary, with Fisher’s exact test. The level of significance was set at α = 0,05. Results. There are significantly more patients with ulcerative colitis without biological therapy in comparison to those with Crohn's disease with biological treatment (Fisher exact test, p = 0,007). With anemia as a result of bleeding, fistulas are the most common complication. The occurrence of fistulas is significantly present with patients on biological therapy (Fisher's exact test, p = 0,007), while the bleeding is significantly present in 11 (61,1%) subjects with no biological treatment. According to 46 patients (73%) the impact of their illness on the quality of life is the best understood by gastroenterologists whereas 23 patients (36,5%) name the nurses from the Gastroenterology Department (Fisher’s exact test, p = 0,047). A significantly greater number of patients, even 20 of them (44,4%), claim that it is due to the biological therapy. These figures are the reason why significantly more respondents on biological therapy (29 of them or 70,7%) are familiar with the course and possible complications of biological therapy (2test, p = 0,017). On a scale from 4 to 10, the respondents rated their satisfaction with the quality of life since starting with the biological treatment with grade 8. Conclusion. After the survey and statistical analysis of data, it can be concluded that the respondents are satisfied with the results of biological therapy and with the work of health personnel involved in the application of this therapy. |
