Objectives: The purpose of this research is documenting medical, social, traditional and technical reasons for not responding to the National Breast Cancer Prevention Program, and investigating reasons of such a lack of response. Furthermore, it will suggest procedures which may concern nurses as part of the family medicine team in an effort to increase that responsiveness. Study design: The study is retrospective. Participants and Methods: Research included women age 50-69 who did not respond to the call of the County Public Health Institute to take part in the National Breast Cancer Prevention Program, didn't do mammograms according to the recommendation of family physicians, nurses or health visitors. For this research a standardized questionnaire was designed for the project's needs, including questions about age, current residence and about reasons for not responding to the National Breast Cancer Prevention Program. Results: 57% of women in the urban area and 43% of women in the village participated in the study. The main reason for not responding to mammographic screening treatment appears to be traditional for urban women and social for women living in a village. Conclusion: Nurse's activities can affect response to the National Breast Cancer Prevention Program by helping women to acquire necessary knowledge and motivation to change their behavior. In practice, nurse should use his/her knowledge, skills and abilities to identify problems, solve them by applying standard methods of health care or include other health care personnel if they are unable to solve the problem themselves.