Objectives: The aim of this study was to evaluate the success of vertebroplasty in the treatment of metastatic spinal fractures by comparing the clinical features before and after the surgical procedure. The success of the surgery is defined by the increased or reduced intensity of pain using the VAS-scale before and after the treatment. Study design: The research is formed as a retrospective-prospective study. The study was conducted on 43 patients, of whom 22 were male and 21 female. Participants and methods: Data was collected at the Institute for Orthopedics and Traumatology at Clinical Hospital Center Osijek on patients who had spinal fractures caused by metastatic disease and were treated with vertebroplasty. The analyzed data included: gender, age, primary disease, pathohistologically proven metastasis in the vertebral body, localization of the fracture and intensity of pain before and after the treatment (using VAS-scale). Results: The largest number of patients had fractures of L1 (7/43) and Th11 (7/43) vertebrae. The difference in pain intensity before and after vertebroplasty was statistically significant and it indicated the success of this surgical method. All patients experienced pain before surgery and it was median 8, while after the surgery it was significantly reduced in all patients and it was median 3. Conclusion: Significant improvement has been recorded in the clinical results of vertebral fractures caused by metastatic disease that were treated by vertebroplasy and it is thus proven that this method of treatment is successful.