| Abstract | Cilj istraživanja: Glavni cilj ovog istraživanja je prikazati povezanost između razine glukoze u plazmi (< 7,7 mmol/l) i bolničkog ishoda bolesnika koji nisu dijabetičari, s preboljelim akutnim koronarnim sindromom (STEMI, NSTEMI). Nacrt studije: Presječna studija s povijesnim podatcima. Ispitanici i metode: U istraživanju je sudjelovalo 139 s dijagnozom akutnog infarkta miokarda (NSTEMI i STEMI), a koji nemaju šećernu bolest. Uspoređene su sljedeće vrijednosti među trima skupinama prema razini šećera u krvi: GUP, HbA1c, kreatinin, pušenje, dob, kolesterol HDL, LDL, trigliceridi, hipertenzija, NT pro-BNP, nalaz PCI (bez stenta, dobio stent, ili preporuka CABG), UZV srca (ejekcijska frakcija, sistolička funkcija, dijastolička funkcija) te ishodi tijekom hospitalizacije (maligne aritmije, srčano zatajenje, dužina hospitalizacije, smrtni ishod). Praćen je i utjecaj konkomitantne terapije s mogućim utjecajem na kardiovaskularne ishode: statini, antihipertenzivi, acetilsalicilna kiselina, antikoagulansi. Za statističku analizu korišten je statistički program MedCalc Statistical Software version 18.11.3 (MedCalc Software bvba, Ostend, Belgium; https://www.medcalc.org; 2019) i SPSS (inačica 16.0, SPSS Inc., Chicago, IL, SAD). Rezultati: Prva skupina ispitanika, s najnižim GUP-om < 5,6 mmol/l u prosjeku je bila značajno mlađa od ostale dvije skupine ispitanika. Bolest zalistaka ima značajnije više ispitanika s vrijednostima GUP-a od 5,6 mmol/L do 6,9 mmol/L, u odnosu na ispitanike s nižim, odnosno višim GUP-om. U slučaju smrtnog ishoda i srčanog zatajenja, ispitanici nisu značajnije više uzimali acetilsalicilnu kiselinu kao konkomitantnu terapiju. Ostali parametri nisu se pokazali značajnima prema vrijednostima glukoze u plazmi. Zaključak: Rezultati istraživanja pokazali su da blago povišene razine glukoze nemaju značajan utjecaj na ishod akutnog koronarnog sindroma, što potvrđuju i malobrojne provedene studije na tu temu. |
| Abstract (english) | Objectives: The aim of the study was to report the correlation between plasma glucose levels (< 7.7 mmol/L) and hospital outcomes of non-diabetic patients with acute coronary syndrome (STEMI, NSTEMI). Study design: Cross-sectional study with historical data. Participants and Methods: The study included 139 patients with acute myocardial infarction (NSTEMI and STEMI), who did not have diabetes. Three groups were formed, on account of the blood glucose levels. The following values were compared between the three groups: GUP, HbA1c, creatinine, smoking, age, HDL, LDL, triglycerides, hypertension, NT pro-BNP, PCI finding (no stent, stent, or CABG recommendation), heart ultrasound (ejection fraction, systolic function, diastolic function) and outcome during hospitalization (malignant arrhythmia, cardiac failure, hospitalization length, death). The effect of concomitant therapy with possible influence on cardiovascular outcomes was also studied: statins, antihypertensive agents, acetylsalicylic acid, anticoagulants. The statistical program MedCalc Statistical Software version 18.11.3 (MedCalc Software bvba, Ostend, Belgium; https://www.medcalc.org; 2019) and SPSS (version 16.0, SPSS Inc., Chicago, IL, USA) were used for the statistical analysis. Results: The first group of subjects, those with the lowest GUP < 5.6 mmol/l, was significantly younger than the other two groups. Valve disease was significantly more common in subjects with GUP values from 5.6 mmol/L to 6.9 mmol/L, compared to subjects with lower or higher GUP. In the case of fatal outcome and heart failure, subjects did not excessively use acetylsalicylic acid as concomitant therapy. Other parameters did not show significance in relation to plasma glucose values. Conclusion: Research findings have shown that mildly elevated levels of glucose have no significant effect on the outcome of the acute coronary syndrome, which is confirmed by the few studies conducted on this topic. |
