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master's thesis
Utjecaj hiperbarične oksigenacije na plazmatsku razinu angiotenzina II kod Sprague- Dawley štakora s animalnim modelom šećerne bolesti
2019. urn:nbn:hr:152:442753
Bogunović, Helena
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Bogunović, H. (2019). Utjecaj hiperbarične oksigenacije na plazmatsku razinu angiotenzina II kod Sprague- Dawley štakora s animalnim modelom šećerne bolesti (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:442753

Bogunović, Helena. "Utjecaj hiperbarične oksigenacije na plazmatsku razinu angiotenzina II kod Sprague- Dawley štakora s animalnim modelom šećerne bolesti." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2019. https://urn.nsk.hr/urn:nbn:hr:152:442753

Bogunović, Helena. "Utjecaj hiperbarične oksigenacije na plazmatsku razinu angiotenzina II kod Sprague- Dawley štakora s animalnim modelom šećerne bolesti." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2019. https://urn.nsk.hr/urn:nbn:hr:152:442753

Bogunović, H. (2019). 'Utjecaj hiperbarične oksigenacije na plazmatsku razinu angiotenzina II kod Sprague- Dawley štakora s animalnim modelom šećerne bolesti', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 03 November 2024, https://urn.nsk.hr/urn:nbn:hr:152:442753

Bogunović H. Utjecaj hiperbarične oksigenacije na plazmatsku razinu angiotenzina II kod Sprague- Dawley štakora s animalnim modelom šećerne bolesti [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2019 [cited 2024 November 03] Available at: https://urn.nsk.hr/urn:nbn:hr:152:442753

H. Bogunović, "Utjecaj hiperbarične oksigenacije na plazmatsku razinu angiotenzina II kod Sprague- Dawley štakora s animalnim modelom šećerne bolesti", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:152:442753

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TitleUtjecaj hiperbarične oksigenacije na plazmatsku razinu angiotenzina II kod Sprague- Dawley štakora s animalnim modelom šećerne bolesti
Title (english)The effect of hyperbaric oxygenation on plasma angiotensin II levels in Sprague- Dawley rats with animal model of diabetes mellitus
AuthorHelena Bogunović
MentorAleksandar Kibel (mentor)
Committee memberAnita Matić (predsjednik povjerenstva)
Committee memberInes Drenjančević (član povjerenstva)
Committee memberAleksandar Kibel (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2019-09-24, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract
Cilj istraživanja: Cilj je ovog istraživanja dokazati mijenja li i na koji način hiperbarična oksigenacija razinu plazmatskog angiotenzina II kod štakora s animalnim modelom šećerne bolesti. Nacrt studije: Eksperimentalna studija. Ispitanici i metode: U istraživanju su korišteni Sprague-Dawley štakori s animalnim modelom šećerne bolesti uzrokovanim streptozocinom. Eksperimentalne životinje bilo su podijeljene u 2 skupine, jednu kontrolnu (N=7) i drugu podvrgnutu HBO-u (N=7). Izložena skupina bila je podvrgnuta HBO-u 4 uzastopna dana po 2 sata pod tlakom od 2 bara. Štakori su nakon toga (5. dan) anestezirani i dekapitirani u cilju uzorkovanja krvi iz koje se centrifugiranjem dobila plazma. Iz uzoraka plazme spektrofotometrijskom metodom ELISA izmjerene su koncentracije ANG-a II. Rezultati: Analiza dobivenih podataka pokazuje da nema statistički značajne razlike između kontrolne skupine sa dijabetesom (6,541 (2,8) pg/ml) i skupine dijabetičnih štakora izloženih HBO (4,634 (1,12) pg/ml). (P>0,05, Mann-Whitney U test). Zaključak: Hiperbarična oksigenacija u okviru specifičnog korištenog protokola ne mijenja značajno razinu angiotenzina II u plazmi muških Sprague-Dawley štakora s animalnim modelom šećerne bolesti.
Abstract (english)
Material and methods: Sprague-Dawley rats with an animal model of streptozocin-induced diabetes mellitus were used in the study. The experimental animals were divided into 2 groups, one control (N = 7) and the other subjected to HBO (N = 7). The exposed group was subjected to HBO for 4 consecutive days for 2 hours at a pressure of 2 bar. The rats were then (on the 5thday) anesthetized and decapitated to sample blood from which plasma was obtained by centrifugation. ANG II concentrations were measured from plasma samples by ELISA spectrophotometry. Results: The analysis of the collected data shows that there are no statistically significant differences between the control groups with diabetes (6,541 pg / ml ± 2,804) and the group of diabetic rats exposed to the HBO (4,634 (1,12) pg/ml). (P>0,05, Mann-Whitney U test). Conclusion: Hyperbaric oxygenation in the context of the specific protocol that is being used does not significantly alter plasma angiotensin II levels in male Sprague-Dawley rats with an animal model of diabetes mellitus.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:442753
Study programmeTitle: University graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra medicinsko laboratorijske dijagnostike (magistar/magistra medicinsko laboratorijske dijagnostike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-12-05 12:33:52