Study aim: The aim of this study is to determine the level of entrepreneurial skills in health studies at the School of Medicine and the Faculty of Dental Medicine and Health in Osijek and to determine whether there are significant differences among participants in relation to age, gender, type of study, level of education and representation of subjects focused on health economics. Structure of the study: Cross-sectional study, done during June and July 2019. Participants and methods: Participants in this study were second year undergraduate and integrated students, and second year graduate and fifth year integrated health studies students at the Josip Juraj Strossmayer University of Osijek. The survey was conducted in the form of a questionnaire and was conducted through the online feature "Google Forms". The questionnaire was anonymous and contained general questions about the participant (gender, age, year and type of study), questions related to the socioeconomic status of the participants (average total monthly income, number of household members, place of residence) and questions that were related to the self-assessment of entrepreneurial skills and the participants' attitude about the importance of entrepreneurial skills in health care. Results: 207 students of health studies at the Josip Juraj Strossmayer University of Osijek participated in the study. The results show that students have average entrepreneurial skills. Age, type and level of study, course attendance and participation in extracurricular activities are all related to the development of entrepreneurial skills. Gender is not statistically significant for the development of entrepreneurial skills. Conclusion: Students of health studies have average entrepreneurial skills. Students who have taken a course focused on economics of health and participated in extracurricular activities have developed their entrepreneurial skills more.