Objective: To determine by histological staining the appearance of Gaucher cells in mouse tissues of liver and spleen of the animal model of Gaucher disease and biochemical isolation of lipid rafts and Western blotting method to determine the composition of lipid rafts on the same tissues. Study desing: The study was conducted as a study of couples. Materials and Methods: The liver and spleen tissue of C57BL / 6 mice 3 months of age previously treated with a CBE chemical for the induction of GD was used for the purpose of the study. Tissues were stained with histological staining, imaged and analyzed. The results obtained were processed in Fiji and Statistica 12softwares. Non-fixed tissues were used to isolate lipid rafts. Results: The appearance of Gaucher cells in the tissues of the experimental group was determined. A larger area of white pulp was observed in spleen tissue by toluidine staining. In the liver, multicore hepatocytes were equally represented in the control and experimental groups. The iron density seen by Perls - DAB staining was noticeably higher in the experimental liver tissue. Western blotting was used to determine the successful isolation of lipid rafts from a sample of liver tissue. Conclusion: The initial study does not fully confirm the initial hypothesis of a change in the composition of lipid rafts. The results of the increased concentration of IR-α in the experimental group do not speak to the changes we expect in the induced model of GD. Changes in the white matter content in the spleen of the experimental group, the presence of Flot1 lipid raft markers in lipid raft isolates, and the absence of non-raft TfR markers confirm the hypothesis. It can be concluded that the proposed changes should be applied in future research to ensure a more accurate and objective result.