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master's thesis
Lipoprotein (a) kao čimbenik rizika kod kardioloških bolesnika
2020. urn:nbn:hr:152:759500
Grgurić, Maja
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Grgurić, M. (2020). Lipoprotein (a) kao čimbenik rizika kod kardioloških bolesnika (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:759500

Grgurić, Maja. "Lipoprotein (a) kao čimbenik rizika kod kardioloških bolesnika." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2020. https://urn.nsk.hr/urn:nbn:hr:152:759500

Grgurić, Maja. "Lipoprotein (a) kao čimbenik rizika kod kardioloških bolesnika." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2020. https://urn.nsk.hr/urn:nbn:hr:152:759500

Grgurić, M. (2020). 'Lipoprotein (a) kao čimbenik rizika kod kardioloških bolesnika', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 02 April 2025, https://urn.nsk.hr/urn:nbn:hr:152:759500

Grgurić M. Lipoprotein (a) kao čimbenik rizika kod kardioloških bolesnika [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2020 [cited 2025 April 02] Available at: https://urn.nsk.hr/urn:nbn:hr:152:759500

M. Grgurić, "Lipoprotein (a) kao čimbenik rizika kod kardioloških bolesnika", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:152:759500

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Metadata
TitleLipoprotein (a) kao čimbenik rizika kod kardioloških bolesnika
Title (english)Lipoprotein a, Lp (a) as a risk factor in cardiac patients
AuthorMaja Grgurić
MentorVatroslav Šerić (mentor)
Committee memberLjubica Glavaš-Obrovac (predsjednik povjerenstva)
Committee memberSanja Mandić (član povjerenstva)
Committee memberVatroslav Šerić (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2020-09-29, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Biochemistry
Abstract
Uvod: Ateroskleroza je bolest stijenke krvnih žila čija progresija dovodi do razvoja kardiovaskularnih bolesti. U nastanku ateroskleroze ulogu imaju kolesterol i lipoproteini. Stoga lipidni profil obuhvaća određivanje koncentracije ukupnog kolesterola, HDL kolesterola, LDL kolesterola te triglicerida. Lipoprotein (a) [Lp(a)] neovisni je čimbenik rizika, čijim se određivanjem povećava osjetljivost utvrđivanja rizika za razvoj kardiovaskularnih bolesti. Ciljevi: Procijeniti razinu rizika za... More razvoj kardiovaskularnih bolesti na temelju vrijednosti parametara standardnog lipidnog profila i Lp(a) u uzorcima krvi među svim ispitanicima te procijeniti korisnost određivanja koncentracije Lp(a) svakom kardiološkom pacijentu. Nacrt studije: Presječna studija. Materijal i metode: U istraživanju su korišteni uzorci krvi od 50 kardioloških bolesnika i 30 zdravih ispitanika (kontrolna skupina). Napravljena je analiza koncentracija parametara standardnog lipidnog profila i Lp(a) na instrumentu Beckman Coulter AU680. Dobiveni rezultati obrađeni su pomoću računalnog programa MedCalc. Rezultati: Izmjerene vrijednosti ukupnog kolesterola, LDL kolesterola, triglicerida i Lp(a) u krvi statistički su značajno više u skupini kardioloških bolesnika u odnosu na kontrolnu skupinu, što je dobiveno Mann-Whitneyjevim U testom (P < 0,05 za sve četiri mjerene vrijednosti). Multivarijatnom logističkom regresijom LDL kolesterol pokazao se boljim prediktorom rizika za razvoj kardiovaskularnih bolesti (OR = 2,13; 95 % CI je od 1,21 do 3,77) od Lp(a) (OR = 1,003; 95 % CI je od 1,00 do 1,007). Zaključci: Koncentracije parametara standardnog lipidnog profila i Lp(a) značajno su veće kod kardioloških bolesnika. Stoga je korisno odrediti koncentraciju Lp(a) svakom kardiološkom pacijentu. Less
Abstract (english)
Introduction: Atherosclerosis is a disease of the blood vessel wall whose progression leads to the development of cardiovascular diseases. Cholesterol and lipoproteins are known to play a role in the development of atherosclerosis. Therefore, lipid profile includes the concentrations of total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides. Lipoprotein (a) [Lp(a)] is an independent risk factor, which increases sensitivity of determinating the risk of developing... More cardiovascular disease. Objectives: To assess the level of risk for the development of cardiovascular diseases based on the values of the parameters of standard lipid profile and Lp(a) in blood samples among all subjects and to assess the usefulness of determining the concentration of Lp(a) in each cardiac patient. Study Design: Cross-sectional study. Material and Methods: Blood samples from 50 cardiac patients and 30 healthy subjects (control group) were used in the study. Concentration analyzes of standard lipid profile parameters were performed on the Beckman Coulter AU680. The obtained results were processed using the computer program MedCalc. Results: Measured values of total cholesterol, LDL cholesterol, triglycerides and Lp(a) in blood were statistically significantly higher in the group of cardiac patients compared to the control group, measured using Mann-Whitney U test (P < 0.05 for all four measured values). Multivariate logistic regression of LDL cholesterol proved to be a better risk predictor for the development of cardiovascular disease (OR = 2.13; 95 % CI is from 1.21 to 3.77) than Lp(a) (OR = 1.003; 95 % CI is from 1.00 do 1,007). Conclusion: Concentrations of standard lipid profile parameters and Lp(a) are significantly higher in cardiac patients. Therefore, it is useful to determine the concentration of Lp(a) in each cardiac patient. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:759500
Study programmeTitle: University graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra medicinsko laboratorijske dijagnostike (magistar/magistra medicinsko laboratorijske dijagnostike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-10-14 09:12:00
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