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master's thesis
Analiza postupaka kod preosjetljivosti na nesteroidne protuupalne lijekove
2021. urn:nbn:hr:152:108228
Rajić, Biljana
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Rajić, B. (2021). Analiza postupaka kod preosjetljivosti na nesteroidne protuupalne lijekove (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:108228

Rajić, Biljana. "Analiza postupaka kod preosjetljivosti na nesteroidne protuupalne lijekove." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2021. https://urn.nsk.hr/urn:nbn:hr:152:108228

Rajić, Biljana. "Analiza postupaka kod preosjetljivosti na nesteroidne protuupalne lijekove." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2021. https://urn.nsk.hr/urn:nbn:hr:152:108228

Rajić, B. (2021). 'Analiza postupaka kod preosjetljivosti na nesteroidne protuupalne lijekove', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:152:108228

Rajić B. Analiza postupaka kod preosjetljivosti na nesteroidne protuupalne lijekove [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2021 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:152:108228

B. Rajić, "Analiza postupaka kod preosjetljivosti na nesteroidne protuupalne lijekove", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:152:108228

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Metadata
TitleAnaliza postupaka kod preosjetljivosti na nesteroidne protuupalne lijekove
Title (english)Analysis of management of hypersensitivity to non-steroidal antiinflammatory drugs
AuthorBiljana Rajić
MentorSuzana Mimica (mentor)
Committee memberJasminka Milas-Ahić (predsjednik povjerenstva)
Committee memberIvan Radoš (član povjerenstva)
Committee memberSuzana Mimica (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2021-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Pharmacology and Toxicology
Abstract
Cilj istraživanja: Ispitati učestalost alergijskih i pseudoalergijskih reakcija na NSAIL-e u pacijenata sa suspektnom anamnezom, ispitati povezanost negativnog testa ekspozicije na paracetamol, koksibe i neselektivne NSAIL-e s prethodnom težinom reakcije te ispitati povezanost preosjetljivosti na NSAIL-e s astmom, kroničnom urtikarijom i atopijskom dijatezom. Nacrt studije: presječno istraživanje s povijesnim podatcima Ispitanici i metode: U istraživanje je uključeno 93 pacijenta koji su testirani na preosjetljivost na NSAIL-e u Dnevnoj bolnici s kliničkom farmakologijom KBC-a Osijek od listopada 2016. godine do prosinca 2020. godine. Iz medicinske dokumentacije prikupljeni su demografski podatci, podatci o komorbiditetima, prethodnoj reakciji te metodama i ishodima testiranja. U statističkoj obradi korišteni su Hi-kvadrat i Fisherov egzaktni test. Rezultati: 84 % ispitanika imalo je reakciju preosjetljivosti na NSAIL-e, od toga je 58 % ispitanika imalo pseudoalergijsku reakciju. Ispitanici koji su anamnestički imali tešku reakciju značajno češće su imali negativan test ekspozicijom na paracetamol. Nije bilo značajne razlike u odnosu na negativan test na ekspoziciju koksibima i neselektivnim NSAIL-ima u ispitanika s i bez prethodno teške reakcije preosjetljivosti. U ovoj skupini ispitanika nije nađena povezanosti između postojanja astme, kronične urtikarije i atopije i preosjetljivosti na NSAIL-e. Zaključak: Pseudoalergijske reakcije bile su češća vrsta reakcije na NSAIL-e. Ispitanici s prethodno teškom reakcijom dobro su podnosili paracetamol, koksibe i neselektivne NSAIL-e na testu ekspozicije. Ispitanici s teškom reakcijom češće su imali negativan test ekspozicije na paracetamol. Ispitanici s astmom, kroničnom urtikariju i atopijskom dijatezom nisu imali veći rizik za nastanak reakcije preosjetljivosti na NSAIL-e.
Abstract (english)
Objectives: The aim of this study was to evaluate the incidence of NSAID allergic and pseudoallergic reactions, the relationship between negative provocation test with paracetamol, coxibs, nonselective NSAIDs and severity of the previous reaction, and also to evaluate the relationship between NSAID hypersensitivity and asthma, chronic urticaria or atopy. Study design: cross-sectional study with historical data Subjects and methods: In this study 93 patients were included, that were tested for NSAID hypersensitivity in the Clinical Pharmacology Outpatient Clinic in Clinical Hospital Center in Osijek, in the period from the beginning of October 2016 to the end of December 2020. Demographic data, data on comorbidities, previous reaction and testing methods were collected from archival medical records. The Chi-square and Fisher's exact test were used in the statistical analysis. Results: 84 % of subjects had NSAID hypersensitivity reaction, 58 % of these reactions were pseudoallergic reactions. Subjects with a history of severe reactions had significantly more often a negative provocation test with paracetamol. There was no significant difference in subjects with or without previously severe hypersensitivity reaction compared to the negative provocation test with coxibs and nonselective NSAIDs. In this group of subjects no relationship between the existence of asthma, chronic urticaria or atopy and NSAID hypersensitivity was detected. Conclusion: Pseudoallergic reactions were more common. Subjects with previously severe reaction tolerated well paracetamol, coxibs, and nonselective NSAIDs on the provocation test. Subjects with a severe reaction had more often negative provocation test with paracetamol. Subjects with asthma, chronic urticaria or atopy did not have a higher risk for NSAID hypersensitivity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:108228
Study programmeTitle: University Graduate Studies
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2023-03-20 08:42:19