Age and sex distribution of transitional cell carcinoma observed in patients treated on Department of urology KBC-Osijek Objectives: The aim of this study was to examine the differences in the incidence of urothelial bladder cancer in relation to age and sex of patients, the differences in exposure to the most common risk factors in relation to age and sex and to examine the frequency of certain grade and stage of the malignancy. Study Design: cross-sectional study with historical data Patients and Methods: The study included 74 patients with urothelial bladder cancer. The subjects were men and women of all ages treated at the Department of urology, KBC Osijek in the period from 1.1.2022. to 1.5.2022. Data on age, sex, life habits, existing comorbidities and pathohistological findings of patients were collected from the available medical documentation. Results: The study was conducted on 55 (74 %) men and 19 (26 %) women. The median age of the respondents was 71 years old, ranging from 46 to 90 years. Most patients are aged 71 to 80 years. Considering the risk factors, 41 (59 %) patients have hypertension, 34 (46 %) smoke, 15 (21 %) patients have dyslipidemia, and 11 (16 %) have type 1 diabetes. 5 (21 %) patients consume alcohol and as many has type 2 diabetes. Invasive tumor is present in 21 (31 %) patients. Out of 39 (58 %) patients with high-grade cancer, slightly more, 33 (68 %), were men, but with borderline significance (P = 0.05). Conclusion: The study shows that there is no statistically significant differences in the distribution of patients according to risk factors in relation to gender and age groups, nor in the distribution of patients according to the status and grade of tumors in relation to gender and age groups. Marginal significance was observed in the distribution of patients according to tumor grade in relation to gender.