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master's thesis
Klinička obilježja, dijagnostika i liječenje angioedema
2023. urn:nbn:hr:152:069718
Miletić, Jelena
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Miletić, J. (2023). Klinička obilježja, dijagnostika i liječenje angioedema (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:069718

Miletić, Jelena. "Klinička obilježja, dijagnostika i liječenje angioedema." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2023. https://urn.nsk.hr/urn:nbn:hr:152:069718

Miletić, Jelena. "Klinička obilježja, dijagnostika i liječenje angioedema." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2023. https://urn.nsk.hr/urn:nbn:hr:152:069718

Miletić, J. (2023). 'Klinička obilježja, dijagnostika i liječenje angioedema', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 22 April 2024, https://urn.nsk.hr/urn:nbn:hr:152:069718

Miletić J. Klinička obilježja, dijagnostika i liječenje angioedema [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2023 [cited 2024 April 22] Available at: https://urn.nsk.hr/urn:nbn:hr:152:069718

J. Miletić, "Klinička obilježja, dijagnostika i liječenje angioedema", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:152:069718

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Metadata
TitleKlinička obilježja, dijagnostika i liječenje angioedema
Title (english)Clinical characteristics, diagnosis and treatment of angioedema
AuthorJelena Miletić
MentorJasminka Milas-Ahić (mentor)
Committee memberSuzana Mimica (predsjednik povjerenstva)
Committee memberVlatka Periša (član povjerenstva)
Committee memberJasminka Milas-Ahić (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2023-07-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Medical Biochemistry
Abstract
Cilj istraživanja: Ispitati učestalost pojedinih vrsta angioedema. Ispitati etiopatogenetske čimbenike koji su doveli do nastanka angioedema. Ispitati vrstu primijenjene terapije te ispitati učinkovitost te terapije. Nacrt studije: presječno istraživanje Ispitanici i metode: U istraživanje je bilo uključeno 96 pacijenata s dijagnozom angioedema koji su liječeni ambulantno, stacionarno i putem Dnevne bolnice na Odjelu za reumatologiju, kliničku imunologiju i alergologiju KBC-a Osijek u razdoblju od 01. siječnja 2020. do 31. prosinca 2022. godine. Podatci su prikupljeni iz medicinske dokumentacije. Za statističku obradu podataka korišten je Fisherov egzaktni test. Razina značajnosti je postavljena na Alpha = 0,05. Rezultati: U istraživanju su podjednako bila zastupljena oba spola, a najčešći tip angioedema je onaj posredovan bradikininom (63,5 %) koji se značajnije više povezuje s hipertenzijom (P = 0,006) i antihipertenzivnom terapijom. Meke česti lica su najčešće bile zahvaćene oteklinom (44,8 %). Pozitivan specifični IgE značajnije više prisutan kod histaminskog (mastocitnog) angioedema (P = 0,001). Najčešće propisana terapija su bili antihistaminici. Ispitanici liječeni traneksamičnom kiselinom značajno su stabilnije nego ispitanici na drugoj terapiji (P < 0,001). Zaključak: Angioedem posredovan bradikininom je bila najčešća vrsta angioedema. Ispitanici s hipertenzijom i oni koji su na antihipertenzivnoj terapiji se značajnije više povezuju s angioedemom posredovanim bradikininom, a NSAR s idiopatskim angioedemom. Ispitanici su najčešće liječeni antihistaminicima, dok su ispitanici na terapiji traneksamičnom kiselinom značajno stabilnije.
Abstract (english)
Objectives: The aim of the study was to examine the frequency of certain types of angioedema. Furthermore, the aim was to identify the etiopathogenetic factors that caused angioedema and to examine the type of applied therapy and examine the effectiveness of that therapy. Study design: cross-sectional study Participants and methods: The study included 96 patients of the Department of Rheumatology, Clinical Immunology, and Allergology of UHC Osijek with diagnosed angioedema between January 1, 2020 to December 31, 2022. The data was collected from the medical records. Fisher's exact test was used for the statistical dana processing. The statistical significance was set at α = 0.05. Results: Both men and women were equally represented in the study, and the most common type of angioedema is bradykinin-mediated angioedema (63.5 %), which is significantly more associated with hypertension (P = 0.006) and antihypertensive therapy. Swelling most often affected the soft tissues of the face (44.8 %). Positive specific IgE was significantly higher in histamine-induced angioedema (P = 0.001). The most frequently prescribed therapy was antihistamines. Participants treated with tranexamic acid were significantly more stable (P < 0,001). Conclusion: Bradykinin-mediated angioedema was the most common type of angioedema. Participants with hypertension and those on antihypertensive therapy were more significantly associated with bradykinin-mediated angioedema while NSAIDs with idiopathic angioedema. It was most often treated with antihistamines and participants treated with tranexamic acid were significantly more stable.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:069718
Study programmeTitle: University Graduate Studies
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-14 13:05:01