Research Objective: To investigate the relationship among different inflammatory markers in perinatal infection, their diagnostic value, and their differences in terms of clinical presentation and disease duration. Study Design: A cross-sectional study with historical data. Participants and Methods: The study includes 101 full-term newborns born between 2016 and 2022 in the Department of Pediatrics with Neonatology at the General County Hospital in Požega. Demographic, clinical, and biochemical data were collected from available medical records. Statistical analysis was performed using MedCalc® Statistical Software version 20. Results: Median gestational age was 39+5 weeks and 61 (60.4 %) of newborns were male. Vaginal delivery accounted for 89 participants (88.1 %). The median duration of infection was 7 days. Jaundice, rash, and hypotonia were the most common symptoms observed. The most frequent risk factor was drug therapy / diseases during pregnancy in 13 mothers. (12.9 %). The most commonly isolated pathogen was E. coli in 16 / 22 participants. (72 %). The median CRP value was 26.9 mg/L, and the median PCT value was 2.14 ng/mL. A positive correlation was found between procalcitonin and leukocytes (Rho = 0.402). There is a positive correlation between procalcitonin (Rho = 0.397) and CRP (Rho = 0.353) with disease duration, as well as between CRP and clinical presentation (Rho = 0.108). Conclusion: CRP is a better predictor of perinatal infection than the total leukocyte count and the I/T ratio. PCT is a more specific infection marker than CRP. Higher CRP and PCT values are associated with longer disease duration. Higher CRP values are associated with a more severe clinical presentation.