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master's thesis
Povezanost glikanskog statusa i nalaza DaTSPECT i MRI mozga u bolesnika s Parkinsonovom bolesti
2023. urn:nbn:hr:152:599008
Vuksan, Ante
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Vuksan, A. (2023). Povezanost glikanskog statusa i nalaza DaTSPECT i MRI mozga u bolesnika s Parkinsonovom bolesti (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:599008

Vuksan, Ante. "Povezanost glikanskog statusa i nalaza DaTSPECT i MRI mozga u bolesnika s Parkinsonovom bolesti." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2023. https://urn.nsk.hr/urn:nbn:hr:152:599008

Vuksan, Ante. "Povezanost glikanskog statusa i nalaza DaTSPECT i MRI mozga u bolesnika s Parkinsonovom bolesti." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2023. https://urn.nsk.hr/urn:nbn:hr:152:599008

Vuksan, A. (2023). 'Povezanost glikanskog statusa i nalaza DaTSPECT i MRI mozga u bolesnika s Parkinsonovom bolesti', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 18 November 2024, https://urn.nsk.hr/urn:nbn:hr:152:599008

Vuksan A. Povezanost glikanskog statusa i nalaza DaTSPECT i MRI mozga u bolesnika s Parkinsonovom bolesti [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2023 [cited 2024 November 18] Available at: https://urn.nsk.hr/urn:nbn:hr:152:599008

A. Vuksan, "Povezanost glikanskog statusa i nalaza DaTSPECT i MRI mozga u bolesnika s Parkinsonovom bolesti", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:152:599008

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Metadata
TitlePovezanost glikanskog statusa i nalaza DaTSPECT i MRI mozga u bolesnika s Parkinsonovom bolesti
Title (english)Correlation between glycan status, DaTSPECT and brain MRI in patients with Parkinson`s disease
AuthorAnte Vuksan
MentorSvetlana Tomić (mentor)
Committee memberTajana Turk (predsjednik povjerenstva)
Committee memberDarija Šnajder Mujkić (član povjerenstva)
Committee memberSvetlana Tomić (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2023-09-29, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract
CILJ ISTRAŽIVANJA: ispitati povezanost razine dopaminergičke denervacije s razinama različitih vrsta glikana putem analize primitka radioizotopa nukleusa kaudatusa i putamena DaTSPECT metodom te ispitivanjem povezanosti razine glikana s MRI volumetrijom putamena. NACRT STUDIJE: presječna studija s povijesnim podacima. ISPITANICI I METODE: u istraživanju je sudjelovalo 29 pacijenata s dijagnosticiranom Parkinsonovom bolesti ili Parkinson plus sindromom koji se liječe i kontroliraju u Klinici za neurologiju Kliničkog bolničkog centra Osijek. Podatci o DaTSPECT i MRI nalazima bolesnika prikupljeni su iz informatičkog sustava registra bolesnika. REZULTATI: uočena je povezanost viših vrijednosti glikana zrelosti i smanjenog primitka radioizotopa u nukleus kaudatus i putamen dok su više vrijednosti glikana mladosti i glikana zdravlja korelirale s višim vrijednostima primitka radioizotopa u desni putamen. Nije pronađena nikakva značajna povezanost MRI volumetrije putamena i glikanskih vrijednosti. ZAKLJUČAK: veće vrijednosti glikana zrelosti dovode do manjeg kapaciteta nukleusa kaudatusa i putamena te posljedično i do veće dopaminergičke denervacije dok više vrijednosti glikana zdravlja i glikana mladosti ukazuju na smanjenu dopaminergičku denervaciju.
Abstract (english)
Objectives: to examine the association between the level of dopaminergic denervation and the level of different types of glycans by means of analysis of radioisotope reception of the caudate nucleus and putamen using the DaTSPECT method and by examining the connection between glycan levels and MRI volumetry of the putamen. Study design: cross-sectional study with historical data Participants and methods: 29 patients diagnosed with Parkinson's disease or Parkinson plus syndrome who are treated and monitored at the Clinic for Neurology within the Osijek Hospital Center participated in the research. Data on DaTSPECT and MRI findings of patients were collected from the computer system of the patient registry. Results: a correlation was observed between higher maturity glycan values and reduced radioisotope uptake in the caudate nucleus and putamen while higher youth glycan and health glycan values correlated with higher radioisotope uptake values in the right putamen. No significant correlation between MRI putamen volumetry and glycan values was found. Conclusion: higher values of maturity glycans lead to lower capacity of the caudate nucleus and putamen so consequently to greater dopaminergic denervation, while higher values of health glycans and youth glycans indicate reduced dopaminergic denervation.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:599008
Study programmeTitle: University graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra medicinsko laboratorijske dijagnostike (magistar/magistra medicinsko laboratorijske dijagnostike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-04-04 14:54:10