| Abstract | Cilj istraživanja:
Ispitati povezanost patohistološkog tipa meningeoma s vrijednosti Ki-67 indeksa, s pojavnosti
recidiva i ishodom liječenja. Ispitati razlike u ishodu liječenja i pojavnosti komplikacija s
obzirom na patohistološki tip, vrijednost Ki-67 indeksa i vrstu neurokirurškog liječenja. Ispitati
postoje li razlike u mRS upitniku prije i nakon neurokirurškog liječenja.
Nacrt studije: Prospektivna studija na povijesnim podatcima.
Ispitanici i metode:
Istraživanje je uključivalo pacijente s patohistološki verificiranim spinalnim meningeomom
koji su operirani u Klinici za neurokirurgiju Kliničkog bolničkog centra Osijek od 1990. - 2023.
Svakom pacijentu bilježila se dob i spol, vrsta preoperativne dijagnostike, klinička prezentacija,
lokalizacija tumora prema regiji, vrsta neurokirurškog pristupa na spinalni kanal, opsežnost
kirurškog zahvata, vrsta i učestalost kirurških komplikacija, patohistološki tip i SZO stupanj,
vrijednost indeksa Ki-67, klinički status prije i nakon operacije, pojavnost recidiva tumora,
način liječenja recidiva, klinički ishod nakon liječenja recidiva.
Rezultati:
Usporedbom Ki-67 indeksa i stupnja SZO nije uočena statistički značajna razlika (MannWhitney U test, P 0,55). Kod usporedbe vrste dijagnostike (Fisherov egzaktni test, P 0,48),
neurokirurškog pristupa (P 0,65), opsežnosti neurokirurškog zahvata (P 0,65), kirurških
komplikacija (P >0,99) i recidiva (P 0,37) u odnosu na patohistološki tip meningeoma nije
uočena značajna razlika. Medijan mRS prije zahvata iznosio je 4 (3-5), a nakon zahvata 3 (1,5-
3,5) (Wilcoxonov test, P < 0,001).
Zaključak:
U prva dva cilja nije uočena statistički značajna povezanost. Dok je kod mRS-a prije i nakon
neurokirurškog zahvata uočena statistički značajna razlika. |
| Abstract (english) | Research Objective: To examine the association of pathohistological type of meningiomas
with Ki-67 index values, recurrence rates, and treatment outcomes. To investigate differences
in treatment outcomes and complication rates based on pathohistological type, Ki-67 index
value, and type of neurosurgical treatment. To assess whether there are differences in mRS
questionnaire scores before and after neurosurgical treatment.
Study Design: Prospective study using historical data.
Participants and Methods: The study included patients with pathohistologically verified
spinal meningiomas who underwent surgery at the Department of Neurosurgery, Clinical
Hospital Center Osijek, from 1990 - 2023. Patient data collected included age and gender, type
of preoperative diagnostics, clinical presentation, tumor localization by region, type of
neurosurgical approach to the spinal canal, extent of surgical procedure, type and frequency of
surgical complications, pathohistological type and WHO grade, Ki-67 index value, clinical
status before and after surgery, recurrence rates, treatment modalities for recurrences, and
clinical outcomes after recurrence treatment.
Results: No statistically significant difference was observed in Ki-67 index and WHO grade
comparison (Mann-Whitney U test, P > 0.05). There was no significant difference in the type
of diagnostics (Fisher's exact test, P > 0.05), neurosurgical approach (P > 0.05), extent of
neurosurgical procedure (P > 0.05), surgical complications (P > 0.05), and recurrences (P >
0.05) based on meningioma pathohistological type. The median mRS before the intervention
was 4 (3-5), and after the intervention, it was 3 (1.5-3.5) (Wilcoxon signed-rank test, P < 0.001).
Conclusion: No statistically significant association was observed in the first two objectives.
However, a statistically significant difference was found in mRS scores before and after
neurosurgical intervention. |
