| Abstract | Ciljevi istraživanja: U sklopu izrade završnoga rada provedeno je istraživanje čiji su ciljevi
bili ispitati razlike u učestalosti melanoma s obzirom na dob i lokalizaciju na koži te učestalost
BRAF mutacije u uzorku te odrediti kliničko-patološke karakteristike radi usporedbe BRAF
pozitivnih i BRAF negativnih melanoma.
Nacrt studije: Istraživanje je presječno, a pri pisanju rada upotrijebljeni su povijesni podatci.
Materijali i metode: Istraživanje je provedeno na temelju postojeće medicinske dokumentacije
na Zavodu za patologiju i sudsku medicinu KBC-a Osijek. Prikupljeni su podatci o dobi i spolu
ispitanika te lokalizaciji i veličini promjene, histološkom podtipu melanoma, dubini infiltracije
po Breslowu i Clarku i broju mitoza. Podatci su deskriptivno statistički obrađeni te uspoređeni
s nalazom BRAF mutacije.
Rezultati: Obradom podataka iz arhive nije uočena povezanost prisutnosti BRAF mutacije s
dobi, lokalizacijom, veličinom, razinom inflitracije po Breslowu i Clarku, mitozom,
ulceracijom i razinom ekspresije Ki67. Test je uočio značajnu razliku u pojavnosti lokalizacije
melanoma u odnosu na dob pacijenta.
Zaključak: Na svim je lokalizacijama (trup, gornji ekstremiteti, donji ekstremiteti i vlasište)
melanom češći kod pacijenata starijih od 50 godina, osim kože lica koja je u uzorku prisutna
kod mlađih od 50 godina. |
| Abstract (english) | Objectives: As part of the final thesis, research was conducted with the objectives of examining
the differences in melanoma frequency based on age and skin localization, the frequency of
BRAF mutations in the sample, and determining the clinical and pathological characteristics
for comparing BRAF-positive and BRAF-negative melanomas.
Study Design: The research is cross-sectional, and historical data was used in writing the thesis.
Materials and methods: The research was conducted based on existing medical
documentation from the Department of Pathology and Forensic Medicine at the University
Hospital Osijek. Data was collected on the age and gender of the participants, as well as the
localization and size of the lesion, histological subtype of melanoma, depth of infiltration
according to Breslow and Clark, and the number of mitoses. The data was descriptively
statistically processed and compared with the BRAF mutation findings.
Results: Data analysis from the archive did not show any correlation between the presence of
the BRAF mutation and age, localization, size, Breslow and Clark infiltration level, mitoses,
ulceration, or the level of Ki67 expression. The test revealed a significant difference in the
occurrence of melanoma localization in relation to the patient's age.
Conclusion: Melanoma is more common in patients over 50 in all localizations (trunk, upper
limbs, lower limbs, and scalp), except for facial skin, found in patients younger than 50 in the
sample. |
