prikaz prve stranice dokumenta Dijagnostička vrijednost mioglobina i srčanog proteina koji veže masne kiseline (H-FABP) u akutnom koronarnom sindromu
  Download
PDF 658.79 KB
master's thesis
Dijagnostička vrijednost mioglobina i srčanog proteina koji veže masne kiseline (H-FABP) u akutnom koronarnom sindromu
2017. urn:nbn:hr:152:812670
Šterpin, Saša
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

Cite this document

Šterpin, S. (2017). Dijagnostička vrijednost mioglobina i srčanog proteina koji veže masne kiseline (H-FABP) u akutnom koronarnom sindromu (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:812670

Šterpin, Saša. "Dijagnostička vrijednost mioglobina i srčanog proteina koji veže masne kiseline (H-FABP) u akutnom koronarnom sindromu." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2017. https://urn.nsk.hr/urn:nbn:hr:152:812670

Šterpin, Saša. "Dijagnostička vrijednost mioglobina i srčanog proteina koji veže masne kiseline (H-FABP) u akutnom koronarnom sindromu." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2017. https://urn.nsk.hr/urn:nbn:hr:152:812670

Šterpin, S. (2017). 'Dijagnostička vrijednost mioglobina i srčanog proteina koji veže masne kiseline (H-FABP) u akutnom koronarnom sindromu', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 02 April 2025, https://urn.nsk.hr/urn:nbn:hr:152:812670

Šterpin S. Dijagnostička vrijednost mioglobina i srčanog proteina koji veže masne kiseline (H-FABP) u akutnom koronarnom sindromu [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2017 [cited 2025 April 02] Available at: https://urn.nsk.hr/urn:nbn:hr:152:812670

S. Šterpin, "Dijagnostička vrijednost mioglobina i srčanog proteina koji veže masne kiseline (H-FABP) u akutnom koronarnom sindromu", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:152:812670

Please login to the repository to save this object to your list.
Metadata
TitleDijagnostička vrijednost mioglobina i srčanog proteina koji veže masne kiseline (H-FABP) u akutnom koronarnom sindromu
Title (english)Diagnostic value of myoglobin and heart-type fatty acid binding protein (H-FABP) in acute coronary sindrome
AuthorSaša Šterpin
MentorSanja Mandić (mentor)
Committee memberLjubica Glavaš-Obrovac (predsjednik povjerenstva)
Committee memberVatroslav Šerić (član povjerenstva)
Committee memberSanja Mandić (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2017-07-07, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Biochemistry
Abstract
Cilj istraživanja Cilj je ovog istraživanja usporediti dijagnostički značaj konvencionalnog biljega mioglobina i novijeg biljega, srčanog proteina koji veže masne kiseline u AKS. Nacrt studije Nacrt studije čini presječno istraživanje (prospektivno istraživanje parova). Ispitanici i metode Ispitanici su (N = 94) bili podijeljeni u tri skupine: pacijenti s NSTEMI AIM-om (N = 37), pacijenti s NAP-om (N = 15) te kontrolni ispitanici (N = 42). Ispitanicima je uzeta anamneza te im je napravljen... More EKG. Koncentracije Tnl-a izmjerene su kemiluminiscentnom imunoanalizom baziranoj na LOCI tehnologiji, a koncentracije mioglobina heterogenom imunoanalizom na Dimension EXL s LM analizatoru (Siemens Healthcare Diagnostics Inc., Newark, USA). Mjerenje H-FABP-a je provedeno na Beckman Coulter AU 680 analizatoru (Beckman Coulter Inc., Brea, USA) imunoturbidimetrijskom metodom. Rezultati su obrađeni statističkim programom MedCalc (MedCalc Software, Mariakerke, Belgium). Rezultati Vrijednosti medijana za H-FABP i mioglobin bile su više kod pacijenata s NSTEMI AIM-om u odnosu na pacijente s NAP-om i kontrolne ispitanike; H-FABP: 8,66 vs. 5,41 vs. 5,66 (P = 0,005); mioglobin: 57,8 vs. 48,8 vs. 49,8 (P = 0,047). H-FABP je pokazao bolju specifičnost (59,5 % vs. 50,0 %) i jednaku osjetljivost (78,4 %) u usporedbi s mioglobinom u dijagnostici NSTEMI AIM-a. Zaključak Vrijednosti koncentracija H-FABP-a razlikuju se među ispitivanim skupinama te su kod ispitanika koji su razvili NSTEMI AIM višlje. H-FABP se pokazao ranijim biljegom AIM-a u odnosu na mioglobin, pokazavši jednaku dijagnostičku osjetljivost, ali veću specifičnost od mioglobina pri optimalnim graničnim vrijednostima u dijagnostici NSTEMI AIM-a te se može smatrati obećavajućim srčanim biomarkerom uz TnI. Less
Abstract (english)
Objectives The aim of this study is to compare the diagnostic significance of the conventional myoglobin marker and the new marker, a heart protein that binds fatty acids to ACS. Study Design The study is designed as a cross-sectional study (prospective case-control study). Participants and Methods Participants (N=94) were divided into three groups: patients with NSTEMI AMI (N=37), patients with UAP (N=15) and control group (N=42). Anamnesis was taken from all of the patients and an ECG... More was made. TnI concentration was measured by chemiluminescent immunoassay based on LOCI technology, and myoglobin concentration by heterogeneous immunoassay on Dimension EXL with LM analyser (Siemens Healthcare Diagnostics Inc., Newark, USA). H-FABP measuring was done on the Beckman Coulter AU 680 analyser (Beckman Coulter Inc., Brea, USA) by immunoturbidimetric method. The results were processed in statistical program MedCalc (MedCalc Software, Mariakerke, Belgium). Results Median values for H-FABP and myoglobin were higher in patients with NSTEMI AMI compared to patients with UAP and control subjects; H-FABP: 8.66 vs. 5.41 vs. 5.66 (P=0.005); myoglobin: 57.8 vs. 48.8 vs. 49.8 (P=0.047). H-FABP indicated better specificity (59.5% vs. 50.0%) and equal sensitivity (78.4%) compared to myoglobin in NSTEMI AMI diagnosis. Conclusion The concentration values of H-FABP differ between the studied groups, and in those who developed NSTEMI AMI they are higher. H-FABP proved as earlier AMI marker compared to myoglobin, showing the same diagnostic sensitivity, but greater specificity than myoglobin at optimal limit values in NSTEMI AMI diagnosis and may be considered a promising cardiac biomarker with TnI. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:812670
Study programmeTitle: University graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra medicinsko laboratorijske dijagnostike (magistar/magistra medicinsko laboratorijske dijagnostike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-09-14 11:35:41
accessibility

closeAccessibilityrefresh

If you wish to permanently save changes, click on Save, if not - your settings will be reset when you restart the browser.