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master's thesis
Varijabilnost CYR2 gena kod pacijenata s infarktom miokarda
2017. urn:nbn:hr:152:515510
Zdravčević, Matea
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Zdravčević, M. (2017). Varijabilnost CYR2 gena kod pacijenata s infarktom miokarda (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:515510

Zdravčević, Matea. "Varijabilnost CYR2 gena kod pacijenata s infarktom miokarda." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2017. https://urn.nsk.hr/urn:nbn:hr:152:515510

Zdravčević, Matea. "Varijabilnost CYR2 gena kod pacijenata s infarktom miokarda." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2017. https://urn.nsk.hr/urn:nbn:hr:152:515510

Zdravčević, M. (2017). 'Varijabilnost CYR2 gena kod pacijenata s infarktom miokarda', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 17 December 2024, https://urn.nsk.hr/urn:nbn:hr:152:515510

Zdravčević M. Varijabilnost CYR2 gena kod pacijenata s infarktom miokarda [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2017 [cited 2024 December 17] Available at: https://urn.nsk.hr/urn:nbn:hr:152:515510

M. Zdravčević, "Varijabilnost CYR2 gena kod pacijenata s infarktom miokarda", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:152:515510

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Metadata
TitleVarijabilnost CYR2 gena kod pacijenata s infarktom miokarda
Title (english)Variation in CYR2 gene in patients with myocardial infarction
AuthorMatea Zdravčević
MentorJasenka Wagner (mentor)
Committee memberMarija Heffer (predsjednik povjerenstva)
Committee memberRobert Steiner (član povjerenstva)
Committee memberJasenka Wagner (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2017-09-26, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract
Cilj istraživanja. Cilj istraživanja bio je utvrditi ulogu polimorfizma CYR2 gena kao mogućeg čimbenika podložnosti za nastanak infarkta miokarda. Nacrt studije. Istraživanje slučajeva i kontrola. Ispitanici i metode. Sudionici istraživanja bili su 200 pacijenata u skupini slučajeva s preboljenim infarktom miokarda, hospitaliziranih u Kliničkom bolničkom centru Osijek i 200 ispitanika kontrola odabranih u ordinaciji obiteljskih liječnika. Napravljena je genotipizacija dva polimorfizma CRY2 gena, rs2292912 i rs10838524. Istraživanje je obuhvatilo upitnik za prikupljanje anamnestičkih podataka, vađenje krvi, izolaciju genomske DNA iz pune krvi te genotipizaciju varijanti CRY2 gena primjenom Taqman metodologije za lančanu reakcije polimeraze u stvarnom vremenu. Rezultati. Nije utvrđena povezanost polimorfizama rs2292912 i rs10838524 gena CRY2 s infarktom miokarda. Iznimka je polimorfizam rs2292912 gdje je pronađena statistički značajna razlika u raspodjeli genotipova. Pronađena je povezanost polimorfizma rs10838524 s hipertenzijom u skupini slučajeva, ali ne i u kontrolnoj skupini. Polimorfizam rs2292912 povezan je s dislipidemijom u muških ispitanika skupine slučajeva, dok je u kontrolnoj skupini povezan s pušenjem kod muškaraca. Zaključak. Na temelju dobivenih rezultata može se zaključiti da odabrani polimorfizmi CRY2 gena nisu čimbenici podložnosti za nastanak infarkta miokarda.
Abstract (english)
Objectives. The aim of the research was to determine the role of polymorphism in CRY2 genes as possible susceptibility factors for myocardial infarction. Study design. Case-control study. Participants and methods. The case group consisted of 200 patients with a history of myocardial infarction, hospitalized in the Clinical Hospital Center Osijek. The control group consisted of 200 subjects recruited at general practitioners. Two polymorphisms in CRY2 gene were analyzed: rs2292912 and rs10838524. The study included a questionnaire, blood sampling, isolation of genomic DNA, and genotyping a single nucleotide polymorphisms using the Taqman methodology and polymerase chain reaction in real time. Results. There was no correlation between SNPs rs2292912 and rs10838524 of gene CRY2 with myocardial infarction. SNP rs10838524 is associated with hypertension in the group of cases, whereas SNP rs2292912 is associated with dyslipidemia within male subjects. Conclusion. Based on the results it can be concluded that the selected gene CRY2 polymorphisms do not pose risk of myocardial infarction.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:515510
Study programmeTitle: University graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra medicinsko laboratorijske dijagnostike (magistar/magistra medicinsko laboratorijske dijagnostike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-05-21 11:39:00