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master's thesis
Utjecaj poremećaja funkcije štitnjače na čimbenike rizika kardiovaskularnih bolesti
2017. urn:nbn:hr:152:394009
Čakalić, Antonela
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Čakalić, A. (2017). Utjecaj poremećaja funkcije štitnjače na čimbenike rizika kardiovaskularnih bolesti (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:394009

Čakalić, Antonela. "Utjecaj poremećaja funkcije štitnjače na čimbenike rizika kardiovaskularnih bolesti." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2017. https://urn.nsk.hr/urn:nbn:hr:152:394009

Čakalić, Antonela. "Utjecaj poremećaja funkcije štitnjače na čimbenike rizika kardiovaskularnih bolesti." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2017. https://urn.nsk.hr/urn:nbn:hr:152:394009

Čakalić, A. (2017). 'Utjecaj poremećaja funkcije štitnjače na čimbenike rizika kardiovaskularnih bolesti', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 01 April 2025, https://urn.nsk.hr/urn:nbn:hr:152:394009

Čakalić A. Utjecaj poremećaja funkcije štitnjače na čimbenike rizika kardiovaskularnih bolesti [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2017 [cited 2025 April 01] Available at: https://urn.nsk.hr/urn:nbn:hr:152:394009

A. Čakalić, "Utjecaj poremećaja funkcije štitnjače na čimbenike rizika kardiovaskularnih bolesti", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:152:394009

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Metadata
TitleUtjecaj poremećaja funkcije štitnjače na čimbenike rizika kardiovaskularnih bolesti
Title (english)The thyroid dysfunction influence on the risk factors of cardiovascular diseases
AuthorAntonela Čakalić
MentorSanja Mandić (mentor)
Committee memberLjubica Glavaš-Obrovac (predsjednik povjerenstva)
Committee memberVatroslav Šerić (član povjerenstva)
Committee memberSanja Mandić (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2017-09-21, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract
Uvod:Hormoni štitnjače utječu na brojne fiziološke procese u organizmu, od regulacije rasta stanica i njihove diferencijacije pa sve do regulacije samog metabolizma. Hipotireoza je najčešći endokrinološki poremećaj kojeg prate snižene koncentracijehormona štitnjače, T4 i/ili T3, uz povećanu koncentraciju TSH. Subklinička hipotireoza je kliničko stanje koje prati umjereno povišena koncentracijaTSH u serumu uz istovremeno normalne koncentracije T3 i T4. Cilj istraživanja:Cilj je ovog istraživanja... More ispitati je li subklinička hipotireoza povezana s proaterogenim lipidnim statusom i upalnim biljezima koji se smatraju čimbenicima rizika kardiovaskularnih bolesti. Ispitanici i metode: Istraživanje je provedeno na ženskoj populaciji koja je podijeljena u dvije skupine: I) eutiroidna (N=77; prosječne dobi 63 godine), II) subklinička hipotireoza (N=74; prosječne dobi 61 godina). Uzorci venske krvi dobiveni su venepunkcijom u epruvete s aktivatorom zgrušavanja (Becton, Dickinson and Company, Franklin Lakes, NJ, USA). Koncentracije TSH, FT4, FT3, Anti-TPO i Anti Tg izmjerile su se kemiluminiscentnom imunoanalizom na UniCel DxI 600 imunokemijskom analizatoru (Beckman Coulter Inc., Brea, USA). Kolesterol, trigliceridi, HDL-kolesterol, LDL-kolesterol, Apo A1, Apo B i CRP odredili su se na Beckman Coulter AU 680 analizatoru (Beckman Coulter Inc., Brea, USA) s reagensima iste firme i to CRP, Apo A1 i Apo B imunoturbidimetrijskom metodom, a kolesterol, trigliceridi, HDL-kolesterol i LDL-kolesterol enzimatskom spektrofotometrijskom metodom. Rezultati:Anti-TPO antitijela zastupljenija su u skupini ispitanika sa subkliničkom hipotireozom: 55/74 vs 20/77 u eutireoidnoj skupini (P<0,001; Fisher egzaktni test). Ispitanici sa subkliničkom hipotireozom imali su statistički značajno više prosječne vrijednosti kolesterola (5,97 vs 5,24; P<0,001), LDL-kolesterola (3,38 vs 2,96; P=0,001) i Apo B (1,06 vs 0,92; P<0,001). Ispitivanjem povezanosti TSH s pojedinim parametrima lipidnog statusa dobivena je slaba korelacija samo s kolesterolom (rho=0,25; P=0,002). Zaključak:Istraživanjem je dokazano da funkcija štitnjače može imati važan utjecaj na lipidni profil u našoj populaciji te da bi zbog mogućih potencijalno opasnih posljedica pacijentima sa subkliničkom hipotireozom trebalo provjeriti i lipidni status kako bi se osigurala rana dijagnoza i terapija tog stanja. Less
Abstract (english)
Introduction: Thyroid hormones influence the numerous physiological processes in the body, such as the regulation of cell growth and their differentiation as well as the regulation of the metabolism itself. Hypothyroidism is the most common endocrine disorder associated with decreased thyroid hormone concentrations, T4 and/or T3, along with increased TSH concentration. Subclinical hypothyroidism is a clinical condition monitored by a moderately elevated TSH concentration in the serum with... More normal T3 and T4 concentrations. Objectives: The aim of this study is to examine whether subclinical hypothyroidism is associated with proatherogenic lipid status and inflammatory markers considered to be risk factors for cardiovascular disease. Participants and Methods: The study was conducted on a female population divided into two groups: I) euthyroid (N = 77, mean age 63), II) subclinical hypothyroidism (N = 74, mean age 61 years). Venous blood samples were obtained by venepuncture in clot activator tubes(Becton, Dickinson and Company, Franklin Lakes, NY, theUSA). Concentrations of TSH, FT4, FT3, Anti-TPO and Anti Tg were measured by chemiluminescence immunoassay on the UniCelDxI 600 immunochemical analyser (Beckman Coulter Inc., Brea, USA). Cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, Apo A1, Apo B and CRP were determined on Beckman Coulter AU 680 analyser (Beckman Coulter Inc., Brea, USA) with reagents of the same company including CRP, Apo A1 and Apo B immunoturbidimetric method, while cholesterol, triglycerides, HDL cholesterol and LDL cholesterol were determined by enzymatic spectrophotometric method. Results: Anti-TPO antibodies were more represented in the subclinical hypothyroidism group: 55/74 vs. 20/77 in the euthyroid group (P<0.001; Fisher’s exact test). Subclinical hypothyroidism subjects had statistically significantly higher average cholesterol levels (5.97 vs. 5.24, P<0.001), LDL cholesterol (3.38 vs. 2.96, P=0.001), and Apo B (1.06 vs. 0.92; P<0.001). Examination of TSH correlation with certain lipid status parameters resulted in poor correlation with cholesterol alone (rho=0.25; P=0.002). Conclusion: The research has shown that thyroid function may have an important influence on the lipid profile in our population and that potentially dangerous consequences for patients with subclinical hypothyroidism should also be inspected for lipid status to provide early diagnosis and therapy for this condition. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:394009
Study programmeTitle: University graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra medicinsko laboratorijske dijagnostike (magistar/magistra medicinsko laboratorijske dijagnostike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-05-21 11:48:28
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