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master's thesis
Osobitosti bolesti štitnjače u dječjoj dobi
2018. urn:nbn:hr:152:325530
Tomić, Anja
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Tomić, A. (2018). Osobitosti bolesti štitnjače u dječjoj dobi (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:325530

Tomić, Anja. "Osobitosti bolesti štitnjače u dječjoj dobi." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2018. https://urn.nsk.hr/urn:nbn:hr:152:325530

Tomić, Anja. "Osobitosti bolesti štitnjače u dječjoj dobi." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2018. https://urn.nsk.hr/urn:nbn:hr:152:325530

Tomić, A. (2018). 'Osobitosti bolesti štitnjače u dječjoj dobi', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 20 November 2024, https://urn.nsk.hr/urn:nbn:hr:152:325530

Tomić A. Osobitosti bolesti štitnjače u dječjoj dobi [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2018 [cited 2024 November 20] Available at: https://urn.nsk.hr/urn:nbn:hr:152:325530

A. Tomić, "Osobitosti bolesti štitnjače u dječjoj dobi", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:152:325530

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Metadata
TitleOsobitosti bolesti štitnjače u dječjoj dobi
Title (english)Characteristics of Thyroid Disease in Childhood
AuthorAnja Tomić
MentorSilvija Pušeljić (mentor)
Committee memberVesna Milas (predsjednik povjerenstva)
Committee memberTatjana Bačun (član povjerenstva)
Committee memberSilvija Pušeljić (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2018-09-18, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract
Autoimune bolesti su u porastu u svijetu. U posljednjem desetljeću došlo je do porasta incidencije autoimunih bolesti štitnjače u dječjoj dobi. Cilj: Cilj rada bio je utvrditi incidenciju bolesti štitnjače u populaciji djece liječene u Klinici za pedijatriju KBC-a Osijek, utvrditi je li došlo do povećanja incidencije bolesti štitnjače u dječjoj dobi u 2017. godini u odnosu na 2010. godinu te utvrditi postoji li povezanost pojedinih čimbenika poput anamnestičkih osobitosti, dobi, spola, hormonskog statusa, komorbiditeta i drugih relevantnih podataka uz povećanu incidenciju bolesti štitnjače u dječjoj dobi za dani period Nacrt studije: dvogodišnja retrospektivna studija u dva odvojena promatrana jednogodišnja razdoblja (2010. i 2017. godina). Ispitanici i metode: U istraţivanje su uključeni svi pedijatrijski pacijenti Zavoda za endokrinologiju KBC-a Osijek s dijagnozom bolesti štitnjače obraĎivani u periodu od 01.01.2010. do 31.12.2010. godine te od 01.01.2017 do 31.12.2017. godine, e, a za dobivanje podataka korištena je medicinska dokumentacija. Razlike meĎu varijablama ispitane su pomoću χ2 testa, Fisherovog egzaktnog testa i Mann-Whitneyjevog U testa, a razina statističke značajnosti prihvaćena je za p < 0,05. Rezultati: Došlo je do 2.4 većeg porasta incidencije bolesti štitnjače, 9.7 puta većeg porasta incidencije autoimunih tireoiditisa, 9.75 puta većeg porasta incidencije nespecificirane hipotireoze, trostrukog porasta u incidenciji netoksične strume, a o ostale neklasificirane bolesti štitnjače su takoĎer u statistički značajnom porastu. Analizom pojedinih čimbenika poput anamnestičkih osobitosti, dobi, spola, hormonskog statusa, komorbiditeta i drugih relevantnih podataka ne moţe se objasniti povećana incidencija bolesti štitnjače. Zaključak: Incidencija bolesti štitnjače uvjerljivo je porasla u posljednjih 7 godina prateći svjetska kretanja. Potrebno je uloţiti napore kako bi se u potpunosti razjasnio patofiziološki mehanizam nastanka bolesti i pojedinih čimbenika koji dovode do povećane incidencije bolesti štitnjače, što bi potencijalno moglo dovesti do razvoja čitavog spektra naprednijih terapijskih i dijagnostičkih mogućnosti.
Abstract (english)
Autoimmune diseases are on the rise worldwide. In the last decade an increase of incidence of autoimmune thyroid disease in children has been observed. Objective: The aim of the study was to determine the incidence of thyroid disease in the pediatric population treated at the Pediatric Clinic of Osijek; to determine if there was a rise of thyroid disease incidence in pediatric population in 2010 and 2017; and to determine whether there was any association with certain factors such as anamnestic features, age, gender, hormonal status, comorbidity, and other relevant factors with an increased incidence of thyroid disease in childhood for a given period. Draft study: two-year retrospective study in two separately observed one-year periods (2010 and 2017) Patients and Methods: All pediatric patients of the Institute for Endocrinology of KBC Osijek with diagnosed thyroid disease were included in the study in the period from January 1st 2010 until December 31st 2010 and from January 1st 2017 until December 31st 2017, and medical data were used to obtain the data. Differences between variables were tested by χ2 test, Fisher's exact test, and Mann-Whitney's U test, and the level of statistical significance was accepted for p <0.05. Results: There was a 2.4-fold increase in thyroid disease approximated incidence, 9.7-fold higher approximated incidence of autoimmune thyroiditis, 9.75-fold higher approximated incidence of unspecified hypothyroidism, triple increase in approximated incidence of non-toxic goitre, and other unclassified thyroid diseases are also statistically significantly on the rise. Analysis of factors such as anamnestic features, age, gender, hormonal status, comorbidity, and other relevant data can not explain the increase of thyroid disease incidence. Conclusion: The incidence of thyroid disease has increased considerably in the last 7 years, following world trends. Efforts should be taken to clarify the mechanisms and factors involved causing thyroid diseases in the pediatric populations. Early detection and evaluation of the disease should be stressed to prevent the development of further complications.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:325530
Study programmeTitle: University Graduate Studies
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2018-12-05 13:09:26