| Abstract | CILJ ISTRAŽIVANJA: U bolesnika s nadomještanjem bubrežne funkcije (NBF) utvrditi prevalenciju Frankova znaka na ušnoj resici i povezanost sa žilnim bolestima. NACRT ISTRAŽIVANJA: Presječno istraživanje. ISPITANICI I POSTUPCI: U 188 bolesnika (60 % muškaraca), 101 na kroničnoj dijalizi i 87 s bubrežnim presatkom, liječenih u Kliničkom bolničkom centru Osijek, medijana dobi 63 godine (interkvartilni raspon 53 – 71), inspekcijom je istraženo postojanje Frankova znaka i ispitani su o simptomima žilne bolesti i pušenju, a podatci o demografskim i kliničkim obilježjima preuzeti su iz medicinskih zapisa. Statistička obrada učinjena je pomoću SPSS-a (inačica 20.0.0, SPSS Inc., Chicago, IL, SAD), a značajnost prihvaćena uz P < 0,05. REZULTATI: Frankov znak imao je 141 (75 %) bolesnik, na desnom uhu 129 (69 %), lijevom 124 (66 %), na oba 112 (59,6 %), češće bolesnici na dijalizi od onih s bubrežnim presatkom (P = 0,01). Bolesnici s Frankovim znakom bili su značajno stariji (P < 0,001). Bolesnici s preboljelim moždanim udarom značajno su češće imali Frankov znak na desnom uhu (P = 0,04). Bolesnici oslabljenog perifernog pulsa značajno su češće imali Frankov znak (P < 0,001). Nije bio značajnije prevalentan u onih sa srčanožilnom bolesti niti u pušača. ZAKLJUČAK: Frankov znak nađen je u većine bolesnika liječenih NBF-om, češće dijalizom nego u onih s bubrežnim presatkom, češće s oslabljenim perifernim pulsom, a na desnom uhu u onih s preboljelim moždanim udarom. Povezan je sa starijom dobi. U bolesnika s NBF-om može upozoriti na moguću žilnu bolest (osobito perifernu i cerebrovaskularnu) i kao jednostavan oku dostupan nalaz usmjeriti dijagnostičku obradu. |
| Abstract (english) | OBJECTIVES: The aim of this study was to determine the prevalence of Frank’s sign in patients on renal replacement therapy and the correlation of Frank’s sign with vascular disease. STUDY DESIGN: Cross-sectional study. PATIENTS AND METHODS: The study included 188 participants (60% male), of which 101 were chronic dialysis patients and 87 had a kidney transplant, all of them being treated at the University Hospital Centre Osijek (UHCO). The median age of the participants was 63 with interquartile range of 53 to 71. A physical examination was done in order to mark down Frank’s sign and acquire data on smoking and vascular disease symptoms. The data on demographic and clinical features was taken from medical records. A statistical analysis was done using SPSS programme (version 20.0.0, SPSS Inc., Chicago, IL, USA) and significance set at P < 0.05. RESULTS: 141 (75%) patients had Frank’s sign, 129 (69%) on the right ear, 124 (66%) on the left ear, and 112 (59.6%) on both ears. Chronic dialysis patients had Frank’s sign more often (P = 0.01). Patients with Frank’s sign were significantly older (P < 0.001). Stroke survivors had Frank’s sign significantly more often on the right ear (P = 0.04). Patients with a weakened peripheral pulse had Frank’s sign significantly more often (P < 0.001). Frank’s sign was not significantly prevalent in smokers nor those with cardiovascular disease. CONCLUSION: Frank’s sign was found in most patients on renal replacement therapy, more often in those on dialysis than in those with a kidney transplant, more often in patients with weakened peripheral pulse and more often on the right ear in stroke survivors. It is related to older age. In patients on renal replacement therapy it can serve as a warning sign of possible vascular disease (especially peripheral and cerebral) and being simple and easily visible it can direct further diagnostic testing. |
