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master's thesis
Utjecaj kratkotrajnog velikog unosa soli na varijabilnost srčanog ritma u zdravih mladih muškaraca
2019. urn:nbn:hr:152:288224
Kolar, Luka
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

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Kolar, L. (2019). Utjecaj kratkotrajnog velikog unosa soli na varijabilnost srčanog ritma u zdravih mladih muškaraca (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:288224

Kolar, Luka. "Utjecaj kratkotrajnog velikog unosa soli na varijabilnost srčanog ritma u zdravih mladih muškaraca." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2019. https://urn.nsk.hr/urn:nbn:hr:152:288224

Kolar, Luka. "Utjecaj kratkotrajnog velikog unosa soli na varijabilnost srčanog ritma u zdravih mladih muškaraca." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2019. https://urn.nsk.hr/urn:nbn:hr:152:288224

Kolar, L. (2019). 'Utjecaj kratkotrajnog velikog unosa soli na varijabilnost srčanog ritma u zdravih mladih muškaraca', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 18 November 2024, https://urn.nsk.hr/urn:nbn:hr:152:288224

Kolar L. Utjecaj kratkotrajnog velikog unosa soli na varijabilnost srčanog ritma u zdravih mladih muškaraca [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2019 [cited 2024 November 18] Available at: https://urn.nsk.hr/urn:nbn:hr:152:288224

L. Kolar, "Utjecaj kratkotrajnog velikog unosa soli na varijabilnost srčanog ritma u zdravih mladih muškaraca", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:152:288224

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TitleUtjecaj kratkotrajnog velikog unosa soli na varijabilnost srčanog ritma u zdravih mladih muškaraca
Title (english)The effect of short-term high-salt diet on heart rate variability in healthy young men
AuthorLuka Kolar
MentorAna Stupin (mentor)
Committee memberInes Drenjančević (predsjednik povjerenstva)
Committee memberAnita Matić (član povjerenstva)
Committee memberAna Stupin (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2019-07-01, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Physiology
Abstract
CILJ ISTRAŽIVANJA: Cilj ovog istraživanja bio je procijeniti aktivnost simpatikusa i parasimpatikusa mjerenjem varijabilnosti srčanog ritma i razine katekolamina te njihovih metabolita u uzorku 24-satnog urina prije i poslije dijete s velikim udjelom kuhinjske soli (HS) u mladih zdravih muškaraca. NACRT STUDIJE: Nerandomizirani kontrolirani klinički pokus. ISPITANICI I METODE: U studiji je sudjelovalo 10 mladih zdravih muškaraca. Ispitanici su bili uključeni u specifični dijetni protokol u trajanju od 14 dana, a koji se sastojao od 7 dana dijete s niskim udjelom soli (~3,5 g soli/dan), i potom 7 dana dijete s visokim udjelom soli (~14 g soli/dan). Aktivnost adrenergičkog sustava mjerena je prije i nakon dijetnih protokola petominutnim testom varijabilnosti srčanog ritma uz pomoć uređaja Heart Rhythm Scanner (Biocom) te određivanjem koncentracije epinefrina, metanefrina, norepinefrina, normetanefrina, dopamina, vanilmandelična kiseline i homovanilična kiseline u uzorku 24-satnog urina. REZULTATI: 7 dana dijete s velikim udjelom soli uzrokovalo je sniženje koncentracije epinefrina i metanefrina u uzorku 24-satnog urina. Analiza vremenske i frekvencijske domene nije pokazala statistički značajne promjene u varijabilnosti srčanog ritma nakon HS protokola kod mladih zdravih muškaraca. ZAKLJUČAK: Iako snižena koncentracija epinefrina i metanefrina u uzorku 24-satnog urina može ukazati na sniženje u aktivnosti simpatikusa zbog HS prehrane, mjerenja varijabilnosti srčanog ritma nisu pokazala značajnu promjenu u aktivnosti simpatikusa ni parasimpatikusa. Ipak, konačan zaključak o utjecaju velikog unosa soli u organizam na aktivnost adrenergičkog sustava bit će donesen nakon uključivanja mladih zdravih žena te povećanja broja ispitanika u studiji.
Abstract (english)
RESEARCH OBJECTIVES: The aim of our project was to assess SNS/parasympathetic (PSNS) activity by measurement of heart rate variability (HRV), and level of catecholamines and their metabolites in 24h urine sample before and after an HS diet protocol in young healthy individuals. STUDY DESIGN: Non-randomized controlled trial. PARTICIPANTS AND METHODS: 10 young healthy men were assigned to a 7-day low salt (LS) diet (<3.5 g salt/day) followed by a 7-day HS diet (~14 g salt/day) (pilot measurements). The 5-minute HRV was assessed by Hearth Rhythm Scanner (Biocom), and 24h-urine epinephrine, metanephrine, norepinephrine, normetanephrine, vanillylmandelic acid (VMA), dopamine, homovanillic acid (HVA) were measured before and after diet protocols. RESULTS: The 7-day HS diet significantly decreased the level of epinephrine and metanephrine in 24h urine samples. Both time domain and frequency domain analysis did not show significant changes in HRV following the HS diet in young healthy men. CONCLUSION: Although reduced epinephrine and metanephrine levels may indicate a decrease in SNS activity due to HS intake, functional measurements of HRV did not show any significant change in both SNS and PSNS activity level following the HS diet in young healthy men. Nevertheless, the final conclusions will be made after the inclusion of young healthy women as well as the increase of the total number of healthy individuals in the present study.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:288224
Study programmeTitle: University Graduate Studies
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-07-22 12:38:59