Objective: The aim of this paper is to research the prevalence of chronic fatigue in patients with migraine and to examine the effect of fatigue on the occurrence of migraine attacks and the quality of life of patients. Study design: The research is organized as a cross-sectional study. Participants and methods: The study involved 30 subjects diagnosed with migraines and treated at the Clinic for Headaches of the Clinic of Neurology, University Hospital Center Osijek. The research tools used included an anonymous questionnaire structured for the purposes of this study, the SF-36 (Short Form Health Survey-36) health status and quality of life questionnaire, as well as Fatigue Severity Scale (FSS) to measure fatigue. Results: There were 27 (90%) females and 3 (10%) males included in the study. There were 16 (53%) respondents who cite fatigue, exhaustion and lack of sleep as a very common trigger of migraine attacks. Also, 20 (67%) respondents stated that they very often feel too tired after a migraine attack, and 8 of them (27%) stated that they always feel too tired after a migraine attack. In most respondents, medications for headache, sedation, allergy, or nausea did not significantly increase the intensity of fatigue. Significantly higher intensity of fatigue measured by FSS was observed in respondents with migraine longer than 72 hours (p<0.03) and frequent migraine (p<0.04). Fatigue was not significantly correlated with pain intensity, the presence of accompanying symptoms or quality of life related to health. Conclusion: In most respondents, fatigue and lack of sleep are the main triggers of migraine headaches. Fatigue as the main symptom after a migraine attack was also observed. Of the total of the observed clinical features affecting migraine (duration of attack, pain intensity, frequency, concomitant symptoms, and migraine therapy), only the duration and frequency of migraine attack are significantly correlated with fatigue intensity in migraine patients. Fatigue does not significantly affect health-related quality of life in migraine patients.