Aim: The objectives of the research were to examine whether the level of anxiety and mental state affect coffee consumption, to examine the relationship between anxiety level and coffee consumption, and to examine the relation of coffee consumption with the anxiety level depending on gender. Study design: The study was organized as a cross-sectional study. Respondents and Methods: The participants in the research were medical students from the Faculty of Medicine in Osijek. An anonymous online questionnaire created for this research, that consisted of two parts, was used as a research instrument. The first part dealt with demographic data and the second part dealt with the assessment of anxiety levels (SAS) and coffee consumption (Motives for Caffeine Consumption Questionnaire). Results: Coffee is consumed by 174 (87 %) respondents. Considering the value of the anxiety scale, 85 (48,9 %) respondents do not have pronounced anxiety while 89 (51,1 %) respondents have pronounced anxiety. Anxiety is significantly higher in respondents who occasionally quite often or almost always/ always consume coffee in stressful situations. There is significantly high agreement with the claims that coffee helps in stressful situations and that coffee helps them to learn better in respondents who consume more coffee. There is no significant difference in the distribution of men and women in relation to their anxiety and coffee consumption. Conclusion: Most respondents have pronounced anxiety. There is no significant difference in the distribution of respondents according to coffee consumption and present anxiety. Considering the respondents who have anxiety, there are significantly more anxious respondents who consume more coffee.