Objectives: To examine the incidence of febrile neutropenia (FN) in patients diagnosed with lymphoproliferative diseases treated with high and moderate risk chemotherapy protocols at the Clinical Hospital Centre Osijek. To examine the incidence of FN in relation to the use of primary prophylaxis with G-CSF. Examine the number of days of hospitalization due to FN. Study Design: Cross-sectional study. Patients and Methods: The study involved 25 patients diagnosed with lymphoproliferative diseases in the period from 01.09.2018. to 15.05.2019 at the Department of Hematology, Clinical Hospital Centre Osijek, who were treated with high and moderate-risk chemotherapy protocols and received primary or secondary prophylaxis with granulocyte colony-stimulating factors (G-CSF). Basic anamnestic data, laboratory data, clinical data on the type of lymphoma, type of chemotherapy, type of prophylaxis and FN incidence were collected from medical history. Results: 25 patients received G-CSF; 21 received G-CSF as primary prophylaxis, and 4 as secondary prophylaxis. 17 patients received LA G-CSF, and 8 patients received filgrastim. FN was registered in 4 (16 %) patients, and all developed FN after the 1st cycle of chemotherapy. 3 patients who received primary prophylaxis developed FN. 5 patients were hospitalized because of FN. In 5 patients, chemotherapy was applied with a delay, and the dose was reduced in 3 patients. The delay in the planned administration of chemotherapy was caused by neutropenia, FN and other toxic effects of chemotherapy. In 4 patients, therapy was discontinued. Conclusion: Primary prophylaxis with G-CSF reduces the incidence of FN, chemotherapy discontinuation due to FN and reduces hospital length of stay. The limitations of our study are its retrospective nature, the small number of included patients and different types of chemotherapy protocols.