Objectives: To examine the neurodevelopmental outcomes of children who experienced an epileptic seizure in the first year of life, and to analyse risk factors from the prenatal and perinatal period with regard to certain characteristics of seizures and the diagnosis of epileptic encephalopathy. Study Design: retrospective cohort study Patients and Methods: The research included 42 patients with the onset of epileptic seizures in the first year of life in the period from January 1, 2018 until December 31, 2019 in the Pediatric Clinic of KBC Osijek. Results: Neurodevelopmental delay were noted in 23 patients, motor developmental delay in 15 patients, speech developmental delay in 16 and in cognitive developmental delay in 14 patients. 8 patients had a behavioral deviation. Neurodevelopmental delays are recorded in children whose mothers had a sustained pregnancy or used medications during pregnancy. Analysing perinatal risk factors, neurodevelopmental delay is significantly associated with prematurity, low birth weight (< 2500 g), low Apgar score in 1' (≤ 7), and with the need for invasive treatment in the early neonatal age. According to brain MR analysis, neurodevelopmental delay is significantly more common in children with intracranial hemorrhage in the early neonatal age, children with brain atrophy, and in those with developmental brain defects. Regarding the etiological characteristics of epilepsy, neurodevelopmental delay is more significant in children who have epilepsy as part of one of the primarily genetic disorders, as well as in those who were born prematurely. Conclusion: Risk factors acting in the prenatal and perinatal period in children with epileptic seizures in the first year of life affect the neurodevelopmental outcome. Neurodevelopmental delay is more severe and associated with epilepsy of genetic etiology and in children with associated developmental defects of the brain.