Aim: To determine the degree of corneal surface damage and changes in the dry film after the application of bevacizumab and the application of povidone iodide; to examine the differences between the quality of the tear film and the surface layer of the cornea of treated and untreated eyes; determine the objective disturbances caused after the application of the drug and compare them with the untreated eye. Study type: Prospective cohort study Participants and methods: Thirty regular patients suffering from exudative SMD were included in the study. In the specified periods, an ophthalmological examination was performed with a biomicroscope and the eye pressure was measured by applanation tonometry along with a tear film break test and filling in the OSDI questionnaire. Results: The day before the procedure, patients have a negative FI value and no stimuli in both eyes. The TBUT test values of the treated eye were significantly lower on the first and seventh day after the procedure compared to the control eye. The OSDI questionnaire in the treated eye records significantly lower values the day before the procedure compared to the first and seventh, while on the thirtieth day after the procedure the values are significantly lower compared to the previous controls. According to the results of the FI test of the treated eye, the FI values before the procedure are significantly different at all measurement points, except for the comparison of the day before and the thirtieth day after the procedure Conclusion: Topical application of povidone-iodide during the application of intravitreal injections leads to subjective problems, discomfort and visual disturbances that are quantitatively expressed by an elevated OSDI index, and are most pronounced up to seven days after the application of the drug, after which we note increased damage to the corneal epithelium, a pronounced stimulus and disturbed and decreased TBUT test in the examined eye, at most seven days after application.