Objectives: The main objective of this study was to analyze the quality control in stroke care in patients registered in the RES-Q stroke registry and to study the impact of the COVID-19 pandemic on them. Study design: Cross-sectional study using historical data. Participants and methods: The research was conducted on all patients with acute stroke over the age of 18 who were hospitalized at the Department of Neurology, "Sveti Duh" Clinical Hospital in Zagreb, in the period between January 1, 2017 and December 31 2022. The data was collected by analyzing the medical history from the RES-Q registry. Results: Recanalization therapy was performed in 41.6 % of patients. 70.1 % of patients were treated in a stroke unit. 10.5 % of patients died. 53 % of patients received a suggestion to quit smoking and statin therapy was introduced in 47.9 %. All subjects with atrial fibrillation received anticoagulant therapy. During 2022, DTN was significantly longer (P = 0.01). 85.6 % of patients received a CT scan within one hour, and 91.3 % were screened for dysphagia. Conclusion: A large percentage of patients received some form of revascularization therapy but a decline was observed during the COVID-19 pandemic. More patients were treated in the stroke unit compared to similar studies. Only about half of the patients recieved a recommendation to quit smoking and statin therapy. The vast majority of patients were screened for dysphagia. Analysis of DTN and DIDO showed comparably good results but they were prolonged during the pandemic. Most patients had a good outcome. The percentage of prescribing antithrombotic therapy meets the highest criteria of the ANGELS Award Initiative.