Research goal: Question the attitudes of high school students considering which school they attend, grade, age, gender and frequency of encountering people with mental retardation (disabilities). Respondents and methods: Respondents were students in the Health and Veterinary School Dr. Andrija Štampar Vinkovci, 3rd and 4th grades, medical nurse/technician of general health care program, as well as the Agricultural and Forestry High School in Vinkovci, 3rd and 4th grades phytopharmacist program. As a research instrument the standardized questionnaire The Multidimensional Attitudes Scale Toward Persons with Disabilities (MAS) was used, authors Findler, Vilchinsky and Werner. Results: There is no difference in attitudes of the students towards people with mental disabilities considering which school they attend (p=0,670). There is a difference in attitude of the respondents in emotional components of their attitude (p=0,002) and the overall scale (p=0,001) considering the school they attend. Those in the 4th grade have a more negative attitude. There is a difference in the respondents' attitudes considering their age in the emotional components of their attitude (p=0,003) and the overall scale (p= 0,001). Females have a more positive attitude towards people with mental disabilities, with a median of 2,5 (inter quartile range of 2,1 – 2,9), but with an insignificant difference. There is no significant difference in the attitudes of students towards people with mental disabilities considering frequency of encounters with a mentally disabled person (p=0,153). Conclusion: High school students have a neutral attitude towards people with mental retardation. There is a difference in individual components of attitudes between the Health and Veterinary high school students and Agricultural and Forestry high school students. The younger students and those who encounter people with mental retardation a few times a week have a more positive attitude.