Objectives. The aim of this study was to examine the quality of life in patients on hemodialysis and correlation between laboratory indicators of inflammation and chronic fatigue. Study design. The study is structured as a cross-section study. Participants and methods. The study was conducted on 110 patients with end stage chronic renal disease in chronic hemodialysis program. The subjective feeling of health was tested using a standard SF-36 health status questionnaire. The questionnaire examines physical, mental or social consequences caused by ill health. The results of the survey were compared to laboratory indicators of inflammation. Results. The highest quality of life is attributed to social functioning and mental health, and the greatest dissatisfaction is the limitation of activity because of the physical health. The overall body activity rating is significantly lower for those with Glasgow Prognostic Score 2 compared to those with Glasgow Prognostic Score 0 or 1. Laboratory indicators of inflammation which correlate positively with domains of quality of life (SF-36) are serum albumin concentrations, platelet counts, and urea concentration in serum before and after hemodialysis. CRP concentration, white blood cell count, RDW values, URR and hemodialysis duration all correlate negatively with domains of quality of life (SF-36). The correlation of hemoglobin concentrations with chronic fatigue and the quality of life of patients treated by hemodialysis has not been demonstrated. Conclusion. Chronic fatigue is a significant problem for patients with end stage chronic renal disease and it affects many aspects of patients’ life.