Objectives: Define the occurrence of burnout syndrome in family physicians and investigate exposure to burnout risk factors and examine the correlation between stress and burnout Study Design: A cross-sectional study. Participants and methods: The survey was conducted on 60 subjects (family physicians), of whom 7 were men and 53 women within the Health Center Osijek in Osijek and the surrounding area. Three questionnaires were used as a survey method. The first was a free questionnaire on possible external causes of stress. It consists of two parts. The first part consists of demographic and personal issues, and the second part is self-assessment of personality. The second was a Perceived Stress Scale and a third standardized self-assessment questionnaire for burnout. Results: Based on the conducted research, 29 respondents were identified as burnout candidates while 7 respondents were affected by burnout. The average exposure to stress belongs to 13 respondents and high levels of stress belong to 28 respondents. Burnout syndrome is associated with stress. Conclusion: The results of the conducted research indicate the high presence of burnout syndrome in family physicians. Most general practitioners belonged to a high level of perceived stress. High levels of stress lead to high levels of burnout. Marital status and children, physical and mental health and higher credit debt are associated with burnout. Religious affiliation and personality traits are linked to higher level of stress.