Objectives: The aim of the research is to determine the quality of life of diabetic patients and to determine whether there is a difference in age, sex, duration of diabetes, type of diabetes, therapy and comorbidities. Study design: The study is a cross-sectional study. Participants and methods: The study included 165 Diabetic Patients of the General Practicioners Department of the Osijek Health Centre. The general questionnaire was used to collect the basic questionnaire, while the standardized Ferrans and Powers questionnaire was used to determine the quality of life index, which measures the results of the overall quality of life and the quality of life in 4 domains: health and functioning, social and economic, psychological and spiritual domains and families. Results: Median of the overall quality of life is 23.2 (scale ranges from 0 to 30). There is no significant difference in the overall quality of life or individual domains as compared to sex, duration of diabetes and therapy. The age is significantly associated with the overall quality of life and the family domain, which means that by increasing age the quality of life and quality of the family domain decreases. Minor health and functioning quality have patients with type II diabetes and patients with macroangiopathy. Conclusion: Quality of life is satisfactory in people with diabetes. Factors that reduce the quality of life are age, type II diabetes and the presence of macroangiopathy. Key words: comorbidity, diabetes mellitus, quality of life, questionnaire