Objective: The aim of the study was to compare the efficacy of epidural steroid injection (ESI) and percutaneous laser disc decompression (PLDD) in patients with lumbar radicular pain. Radicular pain in patients was caused by hernia of intervertebral disc. Furthermore, the aim was to determine whether there is a difference in the efficacy of both methods in treating hernia of intervertebral disc with and without radicular conflict. Study design: prospective cohort study Participants and Methods: Subjects were patients treated at the Clinical Hospital Center Osijek at the Department for Pain Treatment from January to June 2018. 18 patients were treated with ESI method and 10 were treated with PLDD method. In the group where ESI was administered, 9 out of 18 subjects recorded discoradicular conflict, and in the group treated with PLDD, 6 out of 10 recorded discoradicular conflict. The methods used to evaluate the success of the treatment included: the Lasegue test, the Pain Detect questionnaire, and the Oswestry questionnaire. The data from the questionnaires were collected prior to the procedure and on the 15th and 30th day. Results: According to the Pain Detect questionnaire, in patients without discoradicular conflict treated with ESI there was a significant reduction in total neuropathic pain. Significant reduction in pain was also recorded in in patients with discoradicular conflict, treated with PLDD. The Oswestry questionnaire also recorded a significant reduction in the degree of disability in both patients without discoradicular conflict treated with ESI and in patients with discoradicular conflict treated with PLDD. Conclusion: Both methods were successful in subjects without discoradicular conflict. PLDD is a more successful method of treatment in subjects with discoradicular conflict. The ESI method records improvement after 2 weeks, while PLDD has better results after 4 weeks.