Objectives: The aim of this study is to correlate increase of the inflammation markers with the increase of diameter and blood flow of the brachial artery and development of the edema on the dorsum of the fist. Study Design: Prospective study. Participants And Methods: The study included 61 respondents hospitalized in the Intensive care unit of the Clinical Hospital Centre Osijek from December 2020 up to inclusion of planned number of respondents. We measured diameter and flow velocity of the brachial artery and edema of the wrist of the fist within 24 hours since admission and the next day and compared it with the inflammation markers which were closest to the day of the ultrasonic measurement. Results: During study 84 % of the respondents had two ultrasound measurements and no statistical difference was found between the first and the second measurement. We found positive correlation between velocity of flow and CRP and procalcitonin (ρ = 0,59, P = 0,02) and borderline statistical correlation between PCT and edema (ρ = 0,58, P = 0,05). We found positive correlation between leukocytes and edema (ρ = 0,29, P = 0,04). In both ultrasound measurements, the diameter and flow were correlated with high CRP and PCT. The association of diameter and edema in elevated leukocytes in the 1st ultrasound measurement was confirmed. Wrist edema is associated with the length of mechanical ventilation and the outcome of patients treated in the ICU (ρ = 0,40, P = 0,003). Conclusion: No difference was found between the two ultrasound measurements. In the patients with increased inflammatory parameters, the flow and diameter of the artery were increased in both measurements. Tissue swelling was the only parameter associated with the outcomes of the patients treated in the ICU.