Goal of the Research: The Goal of the Research was to determine the exposure to stressfull events in life, personality characteristics, styles of coping with stress of opiates addicts and nonaddicts, and the differences between the factors stated. Determine if there are differences in personality characteristics and styles of coping with stress at opiates addicts at the institutionalized medical treatment and opiates addicts at substitutional therapy in relation to the control group. Draft to the Study: Crossection Research Examinees and Methods: A sample of younger adult men aged 18 to 35 has been encompassed. The Research included a total number of 210 male examinees at the age between 18 and 35, the examinees divided into three groups: 1st group are the opiates addicts (N=70) attending the Institutional treatment program for addiction healing in the Community of „Milosrdni Otac“ in Međugorje (Father of Mercy, Međugorje) who have no psychotic disturbances and had dwelled in the closed type Institution for at least 6 weeks before the inclusion into the Research; 2nd group of opiates addicts (N=70) at the substitutional therapy by Methadone who were directed into the Advisory program due to the Apstinence Syndroms in the Mostar Center for prevention and outpatient addiction treatment (Centar Mostar group). The Examinees of Centar Mostar group have no psychotic disturbances and have been in Apstinency Program for over 6 weeks; 3rd group of examinees are not opiates addicts and have no psychotic disturbances (N=70) including patients of Široki Brijeg Family Medicine Ambulanta (The Control group). The Survey was performed through Questionnary method for which four different questionaries were composed: general demographic questionary, the scale of stressfull life events, the questionary for coping and the questionary for testing the personality type/characteristics. Insight into medical records after three months: Community of Milosrdni Otac in Međugorje – completely maintained apstinence 43 – left the Program 19 – had the relapse 8; Mostar Center for prevention and outpatient addiction treatment – completely maintained apstinence 47 – left the program 10 (2 deceased and 1 in prison) – had the relapse 13. Results: the group of opiates addicts using the institutionalised program and the group of opiates addicts at substitutional therapy by Methadone reached significally higher results at the scale of Stressfull events score and Stressful events summary than the Control group. The addicts from Mostar Centar reached higher results at the scales of Comfort and Neuroticism. The personality characteristics of opiates addicts users of institutionalised treatment that are most helpful in coping with stress are mental avoiding, religion, denial and restraint of confronting. The group of addicts that were institutionalised uses the strategies of mental avoiding, religion and denial in coping with daily stress, which can be explained by attempts of discarding the reality of the stressfull event, psychical separation from the goal with which the stress trigger overlaps through daydreaming, sleeping, autodestructive behaviour and overly relying on belief in God and religious feelings. The most represented manners of confrontation at the examinees who were not addicts are: positive reinterpretation and personality growth, active confrontation with the problem, emotions ventilation, humor, planning, restraint, but also the bihevioral nonengagement and alcohol, and suppressing the competitive activities. The persons who are not addicts statistically use more adaptive mechanisms of confrontation, while the addicts use more maladaptive mechanisms of coping with stress. Conclusion: In this Crossection Research differences were determined between the opiates addicts who are users of Methadone therapy as the treatment method in healing the addiction, and the users of institutionalised addiction recovery program in personality characteristics and strategies of coping with stress. Personality characteristics, like neuroticism and accomodating friendliness, were higher at the addicts who were in the advisory program. It can be the result of emotional tension at confronting the daily requirements and needs of an individual in striving to find an adequate way of coping with stress and the increased requirements.