Objectives: To examine the influence of the platelet count at admission to the hospital on the outcome and severity of stroke in people who underwent revascularization therapy for the treatment of ischemic stroke. To examine the impact of the COVID-19 disease on the outcome and severity of ischemic stroke. Study design: Cross-sectional study with the use of historical sources. Participants and Methods: All patients with acute stroke over the age of 18 who were hospitalized due to acute ischemic stroke in the period from January 1, 2018 were included in the study. until 31.12.2021. By analyzing the medical history, we collected the following data: demographic data (age, gender), cardiomyopathy, hyperlipidemia, arterial hypertension, diabetes, COVID-19 disease, atrial fibrillation, laboratory findings: platelets, MPV (mean platelet volume). Results: Platelets were significantly lower in treated patients with ischemic stroke during the COVID-19 pandemic (Mann Whitney u test, P < 0.001) compared to before the COVID-19 pandemic, while there was no significant difference in MPV values according to the groups. There was no significant difference in platelet and MPV values according to the severity of the clinical picture at discharge. There was no statistically significant difference in platelet and MPV values in COVID-19-positive and COVID-19-negative patients with ischemic stroke. Conclusion: Patients who underwent revascularization had lower values of MPV (mean platelet volume) than those who did not. There is no significant difference in the values of the number of platelets and MPV in relation to the severity of the clinical picture at the discharge of patients with ischemic stroke.